David Rye
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Explore the profile of David Rye including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
1580
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Recent Articles
1.
Skuladottir A, Stefansdottir L, Halldorsson G, Stefansson O, Bjornsdottir A, Jonsson P, et al.
Commun Biol
. 2024 Apr;
7(1):504.
PMID: 38671141
Essential tremor (ET) is a prevalent neurological disorder with a largely unknown underlying biology. In this genome-wide association study meta-analysis, comprising 16,480 ET cases and 1,936,173 controls from seven datasets,...
2.
Ollila H, Sharon E, Lin L, Sinnott-Armstrong N, Ambati A, Yogeshwar S, et al.
Nat Commun
. 2023 May;
14(1):2709.
PMID: 37188663
Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix®. Here, we dissect disease mechanisms...
3.
Salminen A, Clemens S, Garcia-Borreguero D, Ghorayeb I, Li Y, Manconi M, et al.
Dis Model Mech
. 2022 Aug;
15(8).
PMID: 35946581
Our understanding of the causes and natural course of restless legs syndrome (RLS) is incomplete. The lack of objective diagnostic biomarkers remains a challenge for clinical research and for the...
4.
Almuwaqqat Z, Kim J, Islam S, Mehta A, Ahmad S, Wehbe M, et al.
Am J Cardiol
. 2021 Dec;
162:41-48.
PMID: 34903345
The relationship between restless legs syndrome (RLS) and cardiovascular disease remains enigmatic in the general population, and its prognostic value in patients with coronary artery disease (CAD) is unknown. In...
5.
Ambati A, Hillary R, Leu-Semenescu S, Ollila H, Lin L, During E, et al.
Proc Natl Acad Sci U S A
. 2021 Mar;
118(12).
PMID: 33737391
Kleine-Levin syndrome (KLS) is a rare disorder characterized by severe episodic hypersomnia, with cognitive impairment accompanied by apathy or disinhibition. Pathophysiology is unknown, although imaging studies indicate decreased activity in...
6.
Bell S, Rigas A, Magnusson M, Ferkingstad E, Allara E, Bjornsdottir G, et al.
Commun Biol
. 2021 Feb;
4(1):156.
PMID: 33536631
Iron is essential for many biological functions and iron deficiency and overload have major health implications. We performed a meta-analysis of three genome-wide association studies from Iceland, the UK and...
7.
Salminen A, Silvani A, Allen R, Clemens S, Garcia-Borreguero D, Ghorayeb I, et al.
Mov Disord
. 2020 Dec;
36(3):558-569.
PMID: 33382140
Restless legs syndrome (RLS) is a chronic sensorimotor disorder diagnosed by clinical symptoms. It is challenging to translate the diagnostic self-reported features of RLS to animals. To help researchers design...
8.
Connor J, Duck K, Patton S, Simpson I, Trotti L, Allen R, et al.
Fluids Barriers CNS
. 2020 Apr;
17(1):28.
PMID: 32295615
Background: Iron is crucial for proper functioning of all organs including the brain. Deficiencies and excess of iron are common and contribute to substantial morbidity and mortality. Whereas iron's involvement...
9.
Chada A, Dholakia S, Rye D
J Clin Sleep Med
. 2019 Nov;
15(11):1691-1693.
PMID: 31739862
No abstract available.
10.
Gadodia G, Rangaraju S, Raza S, Razzak A, Marmarchi L, Davis B, et al.
Neurologist
. 2018 Mar;
23(2):67-70.
PMID: 29494440
Introduction: Obstructive sleep apnea (OSA) and periodic limb movements (PLMs) have been associated with an increased risk of cardiovascular disease. There is limited data on the relationship between OSA and...