David R W Hodgson
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Explore the profile of David R W Hodgson including associated specialties, affiliations and a list of published articles.
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42
Citations
274
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Recent Articles
1.
Salihovic A, Ascham A, Rosenqvist P, Taladriz-Sender A, Hoskisson P, Hodgson D, et al.
Chem Sci
. 2024 Dec;
16(3):1302-1307.
PMID: 39691463
Ribonucleosides are essential building blocks used extensively in antiviral and oligonucleotide therapeutics. A major challenge in the further development of nucleoside analogues for therapeutic applications is access to scalable and...
2.
Synthesis of 2,2-difluoro-1,3-diketone and 2,2-difluoro-1,3-ketoester derivatives using fluorine gas
Hampton A, Hodgson D, McDougald G, Wang L, Sandford G
Beilstein J Org Chem
. 2024 Mar;
20:460-469.
PMID: 38440170
Solutions of 1,3-diketones and 1,3-ketoester derivatives react with fluorine to give the corresponding 2,2-difluoro-1,3-dicarbonyl derivatives in the presence of quinuclidine. Quinuclidine reacts with fluorine in situ to generate a fluoride...
3.
Murray J, Hodgson D, ODonoghue A
J Org Chem
. 2023 May;
88(12):7619-7629.
PMID: 37126859
Many enzymes work in tandem with small molecule cofactors, which have inspired organocatalyst designs. Chemical modification of cofactor scaffolds has increased organocatalytic reactivity and reaction scope. This synopsis presents a...
4.
Guillen-Garcia A, Gibson S, Jordan C, K Ramaswamy V, Linthwaite V, Bromley E, et al.
Nat Commun
. 2022 Sep;
13(1):5289.
PMID: 36075935
Light harvesting is fundamental for production of ATP and reducing equivalents for CO fixation during photosynthesis. However, electronic energy transfer (EET) through a photosystem can harm the photosynthetic apparatus when...
5.
Linthwaite V, Pawloski W, Pegg H, Townsend P, Thomas M, So V, et al.
Sci Adv
. 2021 Sep;
7(39):eabi5507.
PMID: 34559559
The identification of CO-binding proteins is crucial to understanding CO-regulated molecular processes. CO can form a reversible posttranslational modification through carbamylation of neutral N-terminal α-amino or lysine ε-amino groups. We...
6.
Rozatian N, Hodgson D
Chem Commun (Camb)
. 2020 Dec;
57(6):683-712.
PMID: 33367354
Electrophilic fluorination represents one of the most direct and useful methods available for the selective introduction of fluorine into organic compounds. Electrophilic fluorinating reagents of the N-F class have revolutionised...
7.
Rozatian N, Harsanyi A, Murray B, Hampton A, Chin E, Cook A, et al.
Chemistry
. 2020 Apr;
26(52):12027-12035.
PMID: 32267575
Fluorinated steroids, which are synthesised by electrophilic fluorination, form a significant proportion of marketed pharmaceuticals. To gain quantitative information on fluorination at the 6-position of steroids, kinetics studies were conducted...
8.
Rozatian N, Beeby A, Ashworth I, Sandford G, Hodgson D
Chem Sci
. 2020 Feb;
10(44):10318-10330.
PMID: 32110319
Fluorine-containing 1,3-dicarbonyl derivatives are essential building blocks for drug discovery and manufacture. To understand the factors that determine selectivity between mono- and di-fluorination of 1,3-dicarbonyl systems, we have performed kinetic...
9.
Bose S, Hodgson D
Org Lett
. 2019 Nov;
21(22):9084-9088.
PMID: 31668079
Aminonucleosides are used as key motifs in medicinal and bioconjugate chemistry; however, existing strategies toward 3'-hypernucleophilic amine systems do not readily deliver -configured products. We report diastereoselective syntheses of -...
10.
Rozatian N, Ashworth I, Sandford G, Hodgson D
Chem Sci
. 2019 Jan;
9(46):8692-8702.
PMID: 30595834
Electrophilic N-F fluorination agents underpin the introduction of fluorine in aliphatic systems across drug and academic research. The choice of N-F reagent is currently determined through empirical experimentation in the...