David R Pepperberg
Overview
Explore the profile of David R Pepperberg including associated specialties, affiliations and a list of published articles.
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38
Citations
500
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Recent Articles
1.
Pepperberg D
J Alzheimers Dis
. 2019 Oct;
72(3):663-675.
PMID: 31640091
Cerebral hypoperfusion-induced hypoxia, a condition that impairs oxygen utilization and thus ATP production by mitochondrial oxidative phosphorylation (oxphos), is thought to contribute to neural degeneration in Alzheimer's disease. However, hypoxia...
2.
Carvalho-de-Souza J, Nag O, Oh E, Huston A, Vurgaftman I, Pepperberg D, et al.
ACS Chem Neurosci
. 2018 Dec;
10(3):1478-1487.
PMID: 30589551
Gold nanoparticles (AuNPs) attached to the extracellular leaflet of the plasma membrane of neurons can enable the generation of action potentials (APs) in response to brief pulses of light. Recently...
3.
Carvalho-de-Souza J, Pinto B, Pepperberg D, Bezanilla F
Biophys J
. 2017 Dec;
114(2):283-288.
PMID: 29273263
Millisecond pulses of laser light delivered to gold nanoparticles residing in close proximity to the surface membrane of neurons can induce membrane depolarization and initiate an action potential. An optocapacitance...
4.
Lu Y, Wang B, Pepperberg D, Yao X
Biomed Opt Express
. 2017 Jan;
8(1):38-47.
PMID: 28101399
Transient retinal phototropism (TRP) has been predominantly observed in rod photoreceptors activated by oblique visible light stimulation. Dynamic confocal microscopy and optical coherence tomography (OCT) have revealed rod outer segment...
5.
Luo J, Lee S, VandeVrede L, Qin Z, Piyankarage S, Tavassoli E, et al.
BMC Neurosci
. 2015 Oct;
16:67.
PMID: 26480871
Background: Synaptic dysfunction is a key event in pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD) where synapse loss pathologically correlates with cognitive decline and dementia. Although evidence suggests...
6.
Wang J, Mojumder D, Yan J, Xie A, Standaert R, Qian H, et al.
Exp Eye Res
. 2015 Jul;
139:48-63.
PMID: 26164072
All three classes of receptors for the inhibitory neurotransmitter GABA (GABAR) are expressed in the retina. This study investigated roles of GABAR, especially GABACR (GABA(A)-ρ), in retinal signaling in vivo...
7.
Parthasarathy R, Chow K, Derafshi Z, Fautsch M, Hetling J, Rodgers D, et al.
Exp Eye Res
. 2015 Jul;
138:134-44.
PMID: 26142956
Amyloid-beta (Aβ) is a group of aggregation-prone, 38- to 43-amino acid peptides generated in the eye and other organs. Numerous studies suggest that the excessive build-up of low-molecular-weight soluble oligomers...
8.
Carvalho-de-Souza J, Treger J, Dang B, Kent S, Pepperberg D, Bezanilla F
Neuron
. 2015 Mar;
86(1):207-17.
PMID: 25772189
Unmodified neurons can be directly stimulated with light to produce action potentials, but such techniques have lacked localization of the delivered light energy. Here we show that gold nanoparticles can...
9.
Koduvayur S, Gussin H, Parthasarathy R, Hao Z, Kay B, Pepperberg D
PLoS One
. 2014 Mar;
9(2):e87964.
PMID: 24586298
The abundance and physiological importance of GABAA receptors in the central nervous system make this neurotransmitter receptor an attractive target for localizing diagnostic and therapeutic biomolecules. GABAA receptors are expressed...
10.
VandeVrede L, Tavassoli E, Luo J, Qin Z, Yue L, Pepperberg D, et al.
Br J Pharmacol
. 2013 Oct;
171(2):389-402.
PMID: 24116891
Background And Purpose: Chlormethiazole (CMZ), a clinical sedative/anxiolytic agent, did not reach clinical efficacy in stroke trials despite neuroprotection demonstrated in numerous animal models. Using CMZ as a lead compound,...