David R Nielsen
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Explore the profile of David R Nielsen including associated specialties, affiliations and a list of published articles.
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63
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694
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Recent Articles
1.
Kamoku C, Nielsen D
Biotechnol Prog
. 2025 Jan;
e3518.
PMID: 39846505
The ability to precisely engineer cyanobacterial metabolism first requires the ability to efficiently deliver engineered DNA constructs. Here, we investigate how natural transformation efficiencies in Synechococcus sp. PCC 7002 can...
2.
Jones C, Innes S, Holland S, Burch T, Parrish S, Nielsen D
Biotechnol Bioeng
. 2024 Dec;
122(3):594-605.
PMID: 39696760
Quantification of cyanobacterial CO fixation rates is vital to determining their potential as industrial strains in a circular bioeconomy. Currently, however, CO fixation rates are most often determined through indirect...
3.
Ravindran S, Hajinajaf N, Kundu P, Comes J, Nielsen D, Varman A, et al.
ACS Synth Biol
. 2024 Sep;
13(10):3281-3294.
PMID: 39295585
The ability to convert atmospheric CO and light into biomass and value-added chemicals makes cyanobacteria a promising resource microbial host for biotechnological applications. A newly discovered fastest-growing cyanobacterial strain, sp....
4.
Liu A, Ellis D, Mhatre A, Brahmankar S, Seto J, Nielsen D, et al.
Curr Opin Biotechnol
. 2024 Aug;
89:103178.
PMID: 39098292
Lignin valorization faces persistent biomanufacturing challenges due to the heterogeneous and toxic carbon substrates derived from lignin depolymerization. To address the heterogeneous nature of aromatic feedstocks, plant cell wall engineering...
5.
Godar A, Chase T, Conway D, Ravichandran D, Woodson I, Lai Y, et al.
Bioprocess Biosyst Eng
. 2023 Dec;
47(2):223-233.
PMID: 38142425
Anaerobic succinate fermentations can achieve high-titer, high-yield performance while fixing CO through the reductive branch of the tricarboxylic acid cycle. To provide the needed CO, conventional media is supplemented with...
6.
Liu A, Machas M, Mhatre A, Hajinajaf N, Sarnaik A, Nichols N, et al.
Biotechnol Bioeng
. 2023 Nov;
121(2):784-794.
PMID: 37926950
Efficient co-utilization of mixed sugar feedstocks remains a biomanufacturing challenge, thus motivating ongoing efforts to engineer microbes for improved conversion of glucose-xylose mixtures. This study focuses on enhancing phenylalanine production...
7.
8.
Webb J, Paiva A, Rossoni L, Alstrom-Moore A, Springthorpe V, Vaud S, et al.
Metab Eng
. 2022 Mar;
72:133-149.
PMID: 35289291
Robust systematic approaches for the metabolic engineering of cell factories remain elusive. The available models for predicting phenotypical responses and mechanisms are incomplete, particularly within the context of compound toxicity...
9.
Dookeran Z, Nielsen D
ACS Synth Biol
. 2021 Dec;
10(12):3561-3575.
PMID: 34851612
Amino acids and related targets are typically produced by well-characterized heterotrophs including and . Cyanobacteria offer an opportunity to supplant these sugar-intensive processes by instead directly utilizing atmospheric CO and...
10.
Jones C, Parrish S, Nielsen D
ACS Synth Biol
. 2021 Sep;
10(9):2371-2382.
PMID: 34530614
Here we describe a universal approach for plasmid-free genome engineering in cyanobacteria that exploits the polyploidy of their chromosomes as a natural counterselection system. Rather than being delivered replicating plasmids,...