David R Ladle
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Explore the profile of David R Ladle including associated specialties, affiliations and a list of published articles.
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19
Citations
1008
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Recent Articles
1.
Ladle D, Hippenmeyer S
J Neurophysiol
. 2023 Jan;
PMID: 36695533
Presynaptic inputs determine the pattern of activation of postsynaptic neurons in a neural circuit. Molecular and genetic pathways that regulate the selective formation of subsets of presynaptic inputs are largely...
2.
Iwasawa E, Brown F, Shula C, Kahn F, Lee S, Berta T, et al.
J Neurosci
. 2022 Jan;
42(9):1820-1844.
PMID: 34992132
Neonatal hydrocephalus presents with various degrees of neuroinflammation and long-term neurologic deficits in surgically treated patients, provoking a need for additional medical treatment. We previously reported elevated neuroinflammation and severe...
3.
Walters M, Ladle D
J Neurophysiol
. 2021 Nov;
126(6):1948-1958.
PMID: 34758279
Reflex abnormalities mediated by proprioceptive sensory neurons after peripheral nerve injury (PNI) can limit functional improvement, leaving patients with disability that affects their quality of life. We examined postinjury calcium...
4.
Dupont C, Novak K, Denman K, Myers J, Sullivan J, Walker 2nd P, et al.
Ann Neurol
. 2020 May;
88(2):297-308.
PMID: 32418267
Objective: Myotonia is caused by involuntary firing of skeletal muscle action potentials and causes debilitating stiffness. Current treatments are insufficiently efficacious and associated with side effects. Myotonia can be triggered...
5.
Walters M, Sonner M, Myers J, Ladle D
eNeuro
. 2019 Jul;
6(4).
PMID: 31311802
We investigated the calcium dynamics of dorsal root ganglion (DRG) neurons using transgenic mice to target expression of the genetically encoded calcium indicator (GECI), GCaMP6s, to a subset of neurons...
6.
Sonner P, Ladle D
Neurosci Lett
. 2018 Mar;
674:36-41.
PMID: 29526514
Reciprocal inhibition of motor neurons via Ia inhibitory interneurons recruited by stimulation of proprioceptive afferents supplying antagonist muscles has been well described. Changes in the efficacy of inhibition, and sometimes...
7.
Floyd T, Dai Y, Ladle D
Dev Dyn
. 2017 Nov;
247(1):185-193.
PMID: 29090497
Background: Expression of the calcium binding protein, calbindin (CB), is well established as a hallmark of Renshaw cells, a class of interneurons found in spatially restricted areas in the ventral...
8.
Sonner M, Walters M, Ladle D
PLoS One
. 2017 Jan;
12(1):e0170751.
PMID: 28122055
Muscle proprioceptive afferents provide feedback critical for successful execution of motor tasks via specialized mechanoreceptors housed within skeletal muscles: muscle spindles, supplied by group Ia and group II afferents, and...
9.
OToole S, Ferrer M, Mekonnen J, Zhang H, Shima Y, Ladle D, et al.
J Neurophysiol
. 2016 Dec;
117(3):1057-1069.
PMID: 28003412
Neuronal cell identity is established during development and must be maintained throughout an animal's life (Fishell G, Heintz N. 80: 602-612, 2013). Transcription factors critical for establishing neuronal identity can...
10.
Imai F, Ladle D, Leslie J, Duan X, Rizvi T, Ciraolo G, et al.
J Neurosci
. 2016 May;
36(21):5724-35.
PMID: 27225763
Unlabelled: Spinal reflex circuit development requires the precise regulation of axon trajectories, synaptic specificity, and synapse formation. Of these three crucial steps, the molecular mechanisms underlying synapse formation between group...