David R Kaplan
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Explore the profile of David R Kaplan including associated specialties, affiliations and a list of published articles.
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122
Citations
4893
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Recent Articles
1.
Marymonchyk A, Rodriguez-Aller R, Willis A, Beaupre F, Warsi S, Snapyan M, et al.
Cell Stem Cell
. 2025 Feb;
32(3):445-462.e9.
PMID: 39919748
Life-long maintenance of stem cells implies that feedback mechanisms from the niche regulate their quiescence/activation dynamics. Here, in the mouse adult subventricular neural stem cell (NSC) niche, we charted a...
2.
Willis A, Jeong D, Liu Y, Lithopoulos M, Yuzwa S, Frankland P, et al.
Cell Rep
. 2025 Jan;
44(1):115194.
PMID: 39823226
Here, we used single cell RNA sequencing and single cell spatial transcriptomics to characterize the forebrain neural stem cell (NSC) niche under homeostatic and injury conditions. We defined the dorsal...
3.
Cortes B, Meza R, Ancaten-Gonzalez C, Ardiles N, Aranguiz M, Tomita H, et al.
Biol Res
. 2024 Jun;
57(1):40.
PMID: 38890753
Background: The brain cortex is responsible for many higher-level cognitive functions. Disruptions during cortical development have long-lasting consequences on brain function and are associated with the etiology of brain disorders....
4.
Borisova E, Newman A, Couce Iglesias M, Dannenberg R, Schaub T, Qin B, et al.
Nat Commun
. 2024 Jun;
15(1):4879.
PMID: 38849354
The mammalian neocortex comprises an enormous diversity regarding cell types, morphology, and connectivity. In this work, we discover a post-transcriptional mechanism of gene expression regulation, protein translation, as a determinant...
5.
Dennis D, Wang B, Karamboulas K, Kaplan D, Miller F
Stem Cell Reports
. 2024 Apr;
19(5):654-672.
PMID: 38579710
Here, we used single-cell RNA sequencing (scRNA-seq), single-cell ATAC sequencing (scATAC-seq), and single-cell spatial transcriptomics to characterize murine cortical OPCs throughout postnatal life. During development, we identified two groups of...
6.
Mirmoeini K, Tajdaran K, Zhang J, Gordon T, Ali A, Kaplan D, et al.
Invest Ophthalmol Vis Sci
. 2023 Apr;
64(4):7.
PMID: 37036418
Purpose: Corneal sensory nerves protect the cornea from injury. They are also thought to stimulate limbal stem cells (LSCs) to produce transparent epithelial cells constantly, enabling vision. In other organs,...
7.
Kolaj A, Zahr S, Wang B, Krawec T, Kazan H, Yang G, et al.
Cell Rep
. 2023 Mar;
42(3):112242.
PMID: 36924490
Here, we ask how developing precursors maintain the balance between cell genesis for tissue growth and establishment of adult stem cell pools, focusing on postnatal forebrain neural precursor cells (NPCs)....
8.
Mahmud N, Eisner C, Purushothaman S, Storer M, Kaplan D, Miller F
Cell Rep
. 2022 Dec;
41(12):111853.
PMID: 36543145
Here, we ask why the nail base is essential for mammalian digit tip regeneration, focusing on the inductive nail mesenchyme. We identify a transcriptional signature for these cells that includes...
9.
Ladumor Y, Seong B, Hallett R, Valencia-Sama I, Adderley T, Wang Y, et al.
Mol Cancer Res
. 2022 Feb;
20(6):895-908.
PMID: 35190818
Implications: This newly identified link between VDR signaling and the Hippo pathway could inform treatment strategies for metastatic neuroblastoma.
10.
Fatt M, Tran L, Vetere G, Storer M, Simonetta J, Miller F, et al.
Stem Cell Reports
. 2022 Jan;
17(2):259-275.
PMID: 35063124
Senescent cells are responsible, in part, for tissue decline during aging. Here, we focused on CNS neural precursor cells (NPCs) to ask if this is because senescent cells in stem...