David R Cooper
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Explore the profile of David R Cooper including associated specialties, affiliations and a list of published articles.
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44
Citations
1229
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Recent Articles
11.
Cooper D, Grabowski M, Zimmerman M, Porebski P, Shabalin I, Woinska M, et al.
Methods Mol Biol
. 2020 Oct;
2199:209-236.
PMID: 33125653
Efficient and comprehensive data management is an indispensable component of modern scientific research and requires effective tools for all but the most trivial experiments. The LabDB system developed and used...
12.
Shabalin I, Czub M, Majorek K, Brzezinski D, Grabowski M, Cooper D, et al.
IUCrJ
. 2020 Oct;
7(Pt 6).
PMID: 33063792
Dexamethasone, a widely used corticosteroid, has recently been reported as the first drug to increase the survival chances of patients with severe COVID-19. Therapeutic agents, including dexamethasone, are mostly transported...
13.
Brzezinski D, Kowiel M, Cooper D, Cymborowski M, Grabowski M, Wlodawer A, et al.
Protein Sci
. 2020 Sep;
30(1):115-124.
PMID: 32981130
The COVID-19 pandemic has triggered numerous scientific activities aimed at understanding the SARS-CoV-2 virus and ultimately developing treatments. Structural biologists have already determined hundreds of experimental X-ray, cryo-EM, and NMR...
14.
Shabalin I, Czub M, Majorek K, Brzezinski D, Grabowski M, Cooper D, et al.
bioRxiv
. 2020 Aug;
PMID: 32743572
Dexamethasone, a widely used corticosteroid, has recently been reported as the first drug to increase the survival chances of patients with severe COVID-19. Therapeutic agents, including dexamethasone, are mostly transported...
15.
Czub M, Handing K, Venkataramany B, Cooper D, Shabalin I, Minor W
J Med Chem
. 2020 May;
63(13):6847-6862.
PMID: 32469516
Every day, hundreds of millions of people worldwide take nonsteroidal anti-inflammatory drugs (NSAIDs), often in conjunction with multiple other medications. In the bloodstream, NSAIDs are mostly bound to serum albumin...
16.
Bonarek P, Loch J, Tworzydlo M, Cooper D, Milto K, Wrobel P, et al.
J Struct Biol
. 2020 Mar;
210(2):107493.
PMID: 32169624
Recombinant proteins play an important role in medicine and have diverse applications in industrial biotechnology. Lactoglobulin has shown great potential for use in targeted drug delivery and body fluid detoxification...
17.
Grabowski M, Cymborowski M, Porebski P, Osinski T, Shabalin I, Cooper D, et al.
Struct Dyn
. 2019 Nov;
6(6):064301.
PMID: 31768399
It has been increasingly recognized that preservation and public accessibility of primary experimental data are cornerstones necessary for the reproducibility of empirical sciences. In the field of molecular crystallography, many...
18.
Shabalin I, Gritsunov A, Hou J, Slawek J, Miks C, Cooper D, et al.
FEBS J
. 2019 Nov;
287(11):2235-2255.
PMID: 31750992
Tyrosine biosynthesis via the shikimate pathway is absent in humans and other animals, making it an attractive target for next-generation antibiotics, which is increasingly important due to the looming proliferation...
19.
Lipowska J, Miks C, Kwon K, Shuvalova L, Zheng H, Lewinski K, et al.
Int J Biol Macromol
. 2019 Jun;
136:1176-1187.
PMID: 31207330
The de novo pyrimidine biosynthesis pathway is essential for the proliferation of many pathogens. One of the pathway enzymes, dihydroorotase (DHO), catalyzes the reversible interconversion of N-carbamoyl-l-aspartate to 4,5-dihydroorotate. The...
20.
Hou J, Zheng H, Tzou W, Cooper D, Chruszcz M, Chordia M, et al.
FEBS J
. 2018 Jun;
285(15):2900-2921.
PMID: 29917313
Vibrio cholerae, the causative pathogen of the life-threatening infection cholera, encodes two copies of β-ketoacyl-acyl carrier protein synthase III (vcFabH1 and vcFabH2). vcFabH1 and vcFabH2 are pathogenic proteins associated with...