David R Bonsall
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Explore the profile of David R Bonsall including associated specialties, affiliations and a list of published articles.
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12
Citations
423
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Recent Articles
1.
Piel I, Constantinescu C, de la Puente Bethencourt D, Bonsall D, Rabiner E, Zasadny K, et al.
J Cereb Blood Flow Metab
. 2024 Oct;
:271678X241291949.
PMID: 39479946
This paper describes the preclinical validation of the radioligand [C]ORM-13070 and its tritiated analog for addressing selectivity and occupancy of the selective alpha-2C adrenergic receptor (αR) antagonist BAY 292 in...
2.
Petty A, Garcia-Hidalgo A, Halff E, Natesan S, Withers D, Irvine E, et al.
Mol Imaging Biol
. 2024 Apr;
26(3):553.
PMID: 38570447
No abstract available.
3.
Hognasbacka A, Poot A, Plisson C, Bergare J, Bonsall D, McCluskey S, et al.
EJNMMI Res
. 2024 Feb;
14(1):19.
PMID: 38363422
Background: Mutations in the epidermal growth factor receptor (EGFR) kinase domain are common in non-small cell lung cancer. Conventional tyrosine kinase inhibitors target the mutation site in the ATP binding...
4.
Petty A, Garcia-Hidalgo A, Halff E, Natesan S, Withers D, Irvine E, et al.
Mol Imaging Biol
. 2023 Oct;
25(6):1054-1062.
PMID: 37872462
Purpose: There is robust evidence that people with schizophrenia show elevated dopamine (DA) synthesis capacity in the striatum. This finding comes from positron emission tomography (PET) studies using radiolabelled l-3,4-dihydroxyphenylalanine...
5.
Halff E, Natesan S, Bonsall D, Veronese M, Garcia-Hidalgo A, Kokkinou M, et al.
Mol Imaging
. 2023 Feb;
2022:4419221.
PMID: 36721730
Positron emission tomography (PET) using the radiotracer [F]-FDOPA provides a tool for studying brain dopamine synthesis capacity in animals and humans. We have previously standardised a micro-PET methodology in mice...
6.
Kokkinou M, Irvine E, Bonsall D, Natesan S, Wells L, Smith M, et al.
Mol Psychiatry
. 2020 May;
26(6):2562-2576.
PMID: 32382134
Patients with schizophrenia show increased striatal dopamine synthesis capacity in imaging studies. The mechanism underlying this is unclear but may be due to N-methyl-D-aspartate receptor (NMDAR) hypofunction and parvalbumin (PV)...
7.
Biello S, Bonsall D, Atkinson L, Molyneux P, Harrington M, Lall G
Neurobiol Aging
. 2018 Mar;
66:75-84.
PMID: 29547750
Robust physiological circadian rhythms form an integral part of well-being. The aging process has been found to negatively impact systems that drive circadian physiology, typically manifesting as symptoms associated with...
8.
Bonsall D, Kokkinou M, Veronese M, Coello C, Wells L, Howes O
J Neurochem
. 2017 Sep;
143(5):551-560.
PMID: 28921596
Cocaine is a recreational drug of abuse that binds to the dopamine transporter, preventing reuptake of dopamine into pre-synaptic terminals. The increased presence of synaptic dopamine results in stimulation of...
9.
Calcia M, Bonsall D, Bloomfield P, Selvaraj S, Barichello T, Howes O
Psychopharmacology (Berl)
. 2016 Feb;
233(9):1637-50.
PMID: 26847047
Rationale: Psychosocial stressors are a well-documented risk factor for mental illness. Neuroinflammation, in particular elevated microglial activity, has been proposed to mediate this association. A number of preclinical studies have...
10.
Bonsall D, Kim H, Tocci C, Ndiaye A, Petronzio A, McKay-Corkum G, et al.
PLoS One
. 2015 Oct;
10(10):e0140678.
PMID: 26469939
Fatigue is a disabling symptom in patients with multiple sclerosis and Parkinson's Disease, and is also common in patients with traumatic brain injury, cancer, and inflammatory disorders. Little is known...