David Qualtrough
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Explore the profile of David Qualtrough including associated specialties, affiliations and a list of published articles.
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11
Citations
359
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Recent Articles
1.
Legge D, Collard T, Stanko E, Hoskin A, Holt A, Bull C, et al.
Mol Metab
. 2024 Sep;
90:102037.
PMID: 39332495
Colorectal cancer (CRC) is a multi-stage process initiated through the formation of a benign adenoma, progressing to an invasive carcinoma and finally metastatic spread. Tumour cells must adapt their metabolism...
2.
Shafei M, Flemban A, Daly C, Kendrick P, White P, Dean S, et al.
Breast Cancer
. 2020 Dec;
28(3):592-607.
PMID: 33367952
Background: Biological characterisation of breast cancer subtypes is essential as it informs treatment regimens especially as different subtypes have distinct locoregional patterns. This is related to metabolic phenotype, where altered...
3.
Shafei M, Forshaw T, Davis J, Flemban A, Qualtrough D, Dean S, et al.
Oncotarget
. 2020 Jun;
11(21):1971-1987.
PMID: 32523652
The cytosolic branched chain aminotransferase (BCATc) protein has been found to be highly expressed in breast cancer subtypes, including triple negative breast cancer (TNBC), compared with normal breast tissue. The...
4.
Daly C, Flemban A, Shafei M, Conway M, Qualtrough D, Dean S
Oncol Rep
. 2017 Dec;
39(2):483-490.
PMID: 29207201
A common feature among pre-malignant lesions is the induction of hypoxia through increased cell propagation and reduced access to blood flow. Hypoxia in breast cancer has been associated with poor...
5.
Qualtrough D, Rees P, Speight B, Williams A, Paraskeva C
Cancers (Basel)
. 2015 Sep;
7(3):1885-99.
PMID: 26393651
Colorectal cancer is a major global health problem resulting in over 600,000 deaths world-wide every year with the majority of these due to metastatic disease. Wnt signalling, and more specifically...
6.
Flemban A, Qualtrough D
Cancers (Basel)
. 2015 Sep;
7(3):1863-84.
PMID: 26389956
The epithelium of the lactiferous ducts in the breast is comprised of luminal epithelial cells and underlying basal myoepithelial cells. The regulation of cell fate and transit of cells between...
7.
Qualtrough D, Smallwood K, Littlejohns D, Pignatelli M
BMC Gastroenterol
. 2011 Feb;
11:14.
PMID: 21345224
Background: Fascin is associated with increased cell motility in colorectal tumours but is absent from the normal colonic epithelium. We examined the expression of fascin in inflammatory bowel disease (IBD)...
8.
Qualtrough D, Kaidi A, Chell S, Jabbour H, Williams A, Paraskeva C
Int J Cancer
. 2007 Apr;
121(4):734-40.
PMID: 17437271
Increased expression of cyclooxygenase-2 (COX-2) and subsequent prostaglandin production is an important event in several human malignancies, including colorectal cancer. COX-2 mediated prostanoid synthesis has been shown to play a...
9.
Kaidi A, Qualtrough D, Williams A, Paraskeva C
Cancer Res
. 2006 Jul;
66(13):6683-91.
PMID: 16818642
Cyclooxygenase (COX)-2, the inducible key enzyme for prostanoid biosynthesis, is overexpressed in most colorectal carcinomas and a subset of colorectal adenomas. Genetic, biochemical, and clinical evidence indicates an important role...
10.
Chell S, Witherden I, Dobson R, Moorghen M, Herman A, Qualtrough D, et al.
Cancer Res
. 2006 Mar;
66(6):3106-13.
PMID: 16540660
Cyclooxygenase-2 and prostaglandin E(2) (PGE(2)) levels are increased in colorectal cancers and a subset of adenomas. PGE(2) signaling through the EP4 receptor has previously been associated with colorectal tumorigenesis. However,...