David P Whalley
Overview
Explore the profile of David P Whalley including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
19
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0
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Recent Articles
1.
McCoull W, Addie M, Birch A, Birtles S, Buckett L, Butlin R, et al.
Bioorg Med Chem Lett
. 2012 May;
22(12):3873-8.
PMID: 22608962
A novel series of DGAT-1 inhibitors was discovered from an oxadiazole amide high throughput screening (HTS) hit. Optimisation of potency and ligand lipophilicity efficiency (LLE) resulted in a carboxylic acid...
2.
Bennett S, Campbell A, Hancock A, Johnstone C, Kenny P, Pickup A, et al.
Bioorg Med Chem Lett
. 2010 May;
20(12):3511-4.
PMID: 20493691
A series of carboxylic acid glycogen phosphorylase inhibitors, which have potential as oral antidiabetic agents, is described. Defining and applying simple physicochemical design criteria was used to assess the opportunity...
3.
Whittamore P, Addie M, Bennett S, Birch A, Butters M, Godfrey L, et al.
Bioorg Med Chem Lett
. 2006 Sep;
16(21):5567-71.
PMID: 16945526
Two series of novel thienopyrrole inhibitors of recombinant human liver glycogen phosphorylase a (GPa) which are effective in reducing glucose output from rat hepatocytes are described. Representative compounds have been...