David OBrien
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Explore the profile of David OBrien including associated specialties, affiliations and a list of published articles.
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79
Citations
626
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Recent Articles
1.
Demaegd K, Kernan A, Cooper-Knock J, van Vugt J, Harvey C, Moll T, et al.
Eur J Hum Genet
. 2025 Feb;
PMID: 39956874
Spinocerebellar ataxia type 2 (SCA2) and amyotrophic lateral sclerosis (ALS) are both associated with a CAG-repeat expansion in ATXN2 and with TDP-43-positive neuronal cytoplasmic inclusions. The two disorders have been...
2.
Hoban S, Hvilsom C, Aissi A, Aleixo A, Belanger J, Biala K, et al.
Bioscience
. 2025 Feb;
75(1):47-60.
PMID: 39911160
National, subnational, and supranational entities are creating biodiversity strategy and action plans (BSAPs) to develop concrete commitments and actions to curb biodiversity loss, meet international obligations, and achieve a society...
3.
Murphy S, Carey E, Dablouk L, Alomairi J, Maasarani J, Ong J, et al.
Brain Spine
. 2024 Dec;
4:104134.
PMID: 39687082
Introduction: 'Neurophobia' is a well reported phenomenon in the literature where in medical students and junior doctors have an inherent nervousness or 'fear' of neurology and neurosurgery Research Question: Why...
4.
OBrien D, Shaw P
Br Med Bull
. 2024 Sep;
152(1):4-15.
PMID: 39343443
Introduction: Motor neuron disease (MND) is a devastating neurodegenerative disease characterized by progressive muscle weakness. Sources Of Data: PubMed, MEDLINE, and Cochrane databases were searched for articles to March 2024....
5.
OBrien D, Januszczak I
Wellcome Open Res
. 2024 Sep;
9:325.
PMID: 39233901
We present a genome assembly from an individual male (the European pine marten; Chordata; Mammalia; Carnivora; Mustelidae). The genome sequence is 2,484.6 megabases in span. Most of the assembly is...
6.
Moll T, Harvey C, Alhathli E, Gornall S, OBrien D, Cooper-Knock J
Int Rev Neurobiol
. 2024 May;
176:75-86.
PMID: 38802183
The majority of amyotrophic lateral sclerosis (ALS) is caused by a complex gene-environment interaction. Despite high estimates of heritability, the genetic basis of disease in the majority of ALS patients...
7.
Evans L, OBrien D, Shaw P
Int Rev Neurobiol
. 2024 May;
176:327-384.
PMID: 38802178
Four medications with neuroprotective disease-modifying effects are now in use for motor neuron disease (MND). With FDA approvals for tofersen, relyvrio and edaravone in just the past year, 2022 ended...
8.
Connor K, Conroy E, White K, Shiels L, Keek S, Ibrahim A, et al.
Sci Rep
. 2024 Feb;
14(1):2720.
PMID: 38302657
Here, we establish a CT-radiomics based method for application in invasive, orthotopic rodent brain tumour models. Twenty four NOD/SCID mice were implanted with U87R-Luc2 GBM cells and longitudinally imaged via...
9.
Chamley R, Holland J, Collins J, Pierce K, Watson W, Green P, et al.
Int J Cardiol
. 2023 Nov;
395:131594.
PMID: 37979795
Background: Since the COVID-19 pandemic, post-COVID syndrome (persistent symptoms/complications lasting >12 weeks) continues to pose medical and economic challenges. In military personnel, where optimal fitness is crucial, prolonged limitations affecting...
10.
Tavakol M, OBrien D, Stewart C
Int J Med Educ
. 2023 Sep;
14:123-130.
PMID: 37678838
Objectives: To measure intra-standard-setter variability and assess the variations between the pass marks obtained from Angoff ratings, guided by the latent trait theory as the theoretical model. Methods: A non-experimental...