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David N Proctor

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Articles 75
Citations 2835
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Recent Articles
1.
Dos Santos Pinheiro V, Proctor D, Nogueira Soares R, Alvares T
Am J Physiol Heart Circ Physiol . 2025 Mar; PMID: 40066813
Menopause is associated with reduced nitric oxide (NO) bioavailability, a key contributor to increased arterial stiffness and, consequently, greater risk of cardiovascular disease (CVD)-related mortality in postmenopausal females. Even though...
2.
Gosalia J, Spicuzza J, Bowlus C, Pawelczyk J, Proctor D
Geroscience . 2024 Dec; PMID: 39708217
Metabolic syndrome (MetS) has been linked to accelerated cognitive decline and Alzheimer's disease and related dementias (ADRDs) via cerebral small vessel disease (CSVD); however, this relation in MetS without overt...
3.
Studinski M, Bowlus C, Pawelczyk J, Spicuzza J, Gosalia J, Mookerjee S, et al.
Exp Physiol . 2024 Oct; 110(1):93-105. PMID: 39365983
Younger women rely on altering cardiac output ( ) to regulate blood pressure (BP). In contrast, older women rely more on altering vascular tone. However, evidence suggests that the ability...
4.
Kim D, Gao Z, Luck J, Brandt K, Miller A, Kim-Shapiro D, et al.
Front Nutr . 2024 Jul; 11:1398108. PMID: 39027664
Background: Peripheral arterial disease (PAD) is a prevalent vascular disorder characterized by atherosclerotic occlusion of peripheral arteries, resulting in reduced blood flow to the lower extremities and poor walking ability....
5.
Spicuzza J, Gosalia J, Zhong L, Bondonno C, Petersen K, De Souza M, et al.
Front Nutr . 2024 Jun; 11:1359671. PMID: 38915856
Introduction: Cardiovascular disease (CVD) is the leading cause of death in women, with increased risk following menopause. Dietary intake of beetroot juice and other plant-based nitrate-rich foods is a promising...
6.
Spicuzza J, Gosalia J, Studinski M, Armando C, Alipour E, Kim-Shapiro D, et al.
Can J Physiol Pharmacol . 2024 Jun; 102(11):634-647. PMID: 38901043
Postmenopausal cardiovascular health is a critical determinant of longevity. Consumption of beetroot juice (BR) and other nitrate-rich foods is a safe, effective non-pharmaceutical intervention to increase systemic bioavailability of the...
7.
Somani Y, Boidin M, Peggen M, Wanders I, Proctor D, Low D, et al.
Am J Physiol Regul Integr Comp Physiol . 2023 Oct; 326(1):R79-R87. PMID: 37899755
Whole body exercise provides protection against endothelial ischemia-reperfusion (IR) injury. In this crossover study, we examined the effects of ) single bout of local exercise (handgrip, squats) on endothelial responses...
8.
Spicuzza J, Proctor D, Thijssen D, Somani Y
Physiol Rep . 2023 Sep; 11(18):e15768. PMID: 37734868
Background: In postmenopausal women, reduced ovarian function precedes endothelial dysfunction and attenuated endothelial resistance to ischemia-reperfusion (IR) injury. We hypothesized that IR injury would lower endothelial function, with premenopausal women...
9.
Gardner A, Montgomery P, Wang M, Liang M, Proctor D
Vasc Med . 2023 Feb; 28(2):113-121. PMID: 36847177
Introduction: The aims were (a) to compare the maximal calf conductance and 6-minute walk distance of participants with and without peripheral artery disease (PAD) and claudication, (b) to determine whether...
10.
Gosalia J, Montgomery P, Zhang S, Pomilla W, Wang M, Liang M, et al.
Geroscience . 2022 Aug; 44(6):2831-2844. PMID: 35980564
Age-related vascular alterations promote the pathogenesis of vascular cognitive impairment (VCI). Cardiovascular risk factors that accelerate vascular aging exacerbate VCI. Metabolic syndrome (MetS) constitutes a cluster of critical cardiovascular risk...