David Mole
Overview
Explore the profile of David Mole including associated specialties, affiliations and a list of published articles.
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5
Citations
395
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0
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Recent Articles
1.
Zhuang X, Pedroza-Pacheco I, Nawroth I, Kliszczak A, Magri A, Paes W, et al.
Commun Biol
. 2020 Jul;
3(1):376.
PMID: 32665623
Viral replication is defined by the cellular microenvironment and one key factor is local oxygen tension, where hypoxia inducible factors (HIFs) regulate the cellular response to oxygen. Human immunodeficiency virus...
2.
The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia
Tiana M, Acosta-Iborra B, Puente-Santamaria L, Hernansanz-Agustin P, Worsley-Hunt R, Masson N, et al.
Nucleic Acids Res
. 2017 Oct;
46(1):120-133.
PMID: 29059365
Cells adapt to environmental changes, including fluctuations in oxygen levels, through the induction of specific gene expression programs. To identify genes regulated by hypoxia at the transcriptional level, we pulse-labeled...
3.
Jantsch J, Wiese M, Schodel J, Castiglione K, Glasner J, Kolbe S, et al.
J Leukoc Biol
. 2011 Jun;
90(3):551-62.
PMID: 21685248
HIF1A is a transcription factor that plays a central role for the adaptation to tissue hypoxia and for the inflammatory response of myeloid cells, including DCs. HIF1A is stabilized by...
4.
Thalhammer A, Bencokova Z, Poole R, Loenarz C, Adam J, OFlaherty L, et al.
PLoS One
. 2011 Jan;
6(1):e16210.
PMID: 21264265
Human 2-oxoglutarate oxygenases catalyse a range of biological oxidations including the demethylation of histone and nucleic acid substrates and the hydroxylation of proteins and small molecules. Some of these processes...
5.
Ang S, Chen H, Hirota K, Gordeuk V, Jelinek J, Guan Y, et al.
Nat Genet
. 2002 Nov;
32(4):614-21.
PMID: 12415268
Chuvash polycythemia is an autosomal recessive disorder that is endemic to the mid-Volga River region. We previously mapped the locus associated with Chuvash polycythemia to chromosome 3p25. The gene associated...