David Micklem
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Explore the profile of David Micklem including associated specialties, affiliations and a list of published articles.
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10
Citations
237
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Recent Articles
1.
Arner E, Alzhanova D, Westcott J, Hinz S, Tiron C, Blo M, et al.
Sci Signal
. 2024 Dec;
17(867):eado6057.
PMID: 39689180
The receptor tyrosine kinase AXL promotes tumor progression, metastasis, and therapy resistance through the induction of epithelial-mesenchymal transition (EMT). Here, we found that activation of AXL resulted in the phosphorylation...
2.
Tenstad O, Christakou E, Hodneland Nilsson L, Gausdal G, Micklem D, Kursula P, et al.
Sci Rep
. 2024 Jul;
14(1):16141.
PMID: 38997436
Soluble biomarkers are paramount to personalized medicine. However, the in vivo turnover and biodistribution of soluble proteins is seldom characterized. The cleaved extracellular domain of the AXL receptor (sAXL) is...
3.
Bhalla S, Fattah F, Ahn C, Williams J, Macchiaroli A, Padro J, et al.
Lung Cancer
. 2023 Jul;
182:107291.
PMID: 37423058
Objectives: AXL, a transmembrane receptor tyrosine kinase, is highly expressed and associated with poor prognosis in non-small cell lung cancer (NSCLC). Bemcentinib (BGB324), a selective orally bioavailable small molecule AXL...
4.
Li H, Liu Z, Liu L, Zhang H, Han C, Girard L, et al.
Cell Rep Med
. 2022 May;
3(3):100554.
PMID: 35492873
Mutations in in non-small cell lung cancer (NSCLC) are associated with poor patient responses to immune checkpoint blockade (ICB), and introduction of a () mutation into murine lung adenocarcinomas driven...
5.
Bohan D, Van Ert H, Ruggio N, Rogers K, Badreddine M, Aguilar Briseno J, et al.
PLoS Pathog
. 2021 Nov;
17(11):e1009743.
PMID: 34797899
Phosphatidylserine (PS) receptors enhance infection of many enveloped viruses through virion-associated PS binding that is termed apoptotic mimicry. Here we show that this broadly shared uptake mechanism is utilized by...
6.
Bohan D, Van Ert H, Ruggio N, Rogers K, Badreddine M, Aguilar Briseno J, et al.
bioRxiv
. 2021 Jun;
PMID: 34159331
Phosphatidylserine (PS) receptors are PS binding proteins that mediate uptake of apoptotic bodies. Many enveloped viruses utilize this PS/PS receptor mechanism to adhere to and internalize into the endosomal compartment...
7.
Lotsberg M, Wnuk-Lipinska K, Terry S, Tan T, Lu N, Trachsel-Moncho L, et al.
J Thorac Oncol
. 2020 Feb;
15(6):973-999.
PMID: 32018052
Introduction: Acquired cancer therapy resistance evolves under selection pressure of immune surveillance and favors mechanisms that promote drug resistance through cell survival and immune evasion. AXL receptor tyrosine kinase is...
8.
Nilsson L, Pettersen I, Nikolaisen J, Micklem D, Avsnes Dale H, Rosland G, et al.
Sci Rep
. 2016 Aug;
6:30527.
PMID: 27541795
No abstract available.
9.
Nilsson L, Pettersen I, Nikolaisen J, Micklem D, Avsnes Dale H, Rosland G, et al.
Sci Rep
. 2015 Nov;
5:17217.
PMID: 26596249
Changes in mitochondrial amount and shape are intimately linked to maintenance of cell homeostasis via adaptation of vital functions. Here, we developed a new live-cell reporter strategy to simultaneously monitor...
10.
Kirane A, Ludwig K, Sorrelle N, Haaland G, Sandal T, Ranaweera R, et al.
Cancer Res
. 2015 Jul;
75(18):3699-705.
PMID: 26206560
Repurposing "old" drugs can facilitate rapid clinical translation but necessitates novel mechanistic insight. Warfarin, a vitamin K "antagonist" used clinically for the prevention of thrombosis for more than 50 years,...