David Meierhofer
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Explore the profile of David Meierhofer including associated specialties, affiliations and a list of published articles.
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Articles
90
Citations
1974
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Recent Articles
11.
Mishra H, Schlack-Leigers C, Lim E, Thieck O, Magg T, Raedler J, et al.
Sci Immunol
. 2024 Jan;
9(92):eadi9575.
PMID: 38207015
Hyperactive TLR7 signaling has long been appreciated as driver of autoimmune disease in mouse models. Recently, gain-of-function mutations in TLR7 were identified as a monogenic cause of human lupus. TLR7...
12.
van der Weijden V, Stotzel M, Iyer D, Fauler B, Gralinska E, Shahraz M, et al.
Nat Cell Biol
. 2024 Jan;
26(2):181-193.
PMID: 38177284
Mammalian developmental timing is adjustable in vivo by preserving pre-implantation embryos in a dormant state called diapause. Inhibition of the growth regulator mTOR (mTORi) pauses mouse development in vitro, yet...
13.
Basu S, Martinez-Cristobal P, Frigole-Vivas M, Pesarrodona M, Lewis M, Szulc E, et al.
Nat Struct Mol Biol
. 2023 Dec;
30(12):1958-1969.
PMID: 38049566
Transcription factors are among the most attractive therapeutic targets but are considered largely 'undruggable' in part due to the intrinsically disordered nature of their activation domains. Here we show that...
14.
Panconesi R, Carvalho M, Eden J, Fazi M, Ansari F, Mancina L, et al.
EBioMedicine
. 2023 Nov;
98:104861.
PMID: 37924707
Background: Normothermic regional perfusion (NRP) and hypothermic-oxygenated-perfusion (HOPE), were both shown to improve outcomes after liver transplantation from donors after circulatory death (DCD). Comparative clinical and mechanistical studies are however...
15.
Eden J, Breuer E, Birrer D, Muller M, Pfister M, Mayr H, et al.
EBioMedicine
. 2023 Nov;
98:104857.
PMID: 37918219
Background: To report on a concept of liver assessment during ex situ hypothermic oxygenated perfusion (HOPE) and its significant impact on liver utilization. Methods: An analysis of prospectively collected data...
16.
Koutsoumparis A, Busack I, Chen C, Hayashi Y, Braeckman B, Meierhofer D, et al.
Genetics
. 2023 Sep;
225(2).
PMID: 37682641
Sleep is a fundamental state of behavioral quiescence and physiological restoration. Sleep is controlled by environmental conditions, indicating a complex regulation of sleep by multiple processes. Our knowledge of the...
17.
Morse P, Perez-Mejias G, Wan J, Turner A, Marquez I, Kalpage H, et al.
Nat Commun
. 2023 Jul;
14(1):4166.
PMID: 37443314
Skeletal muscle is more resilient to ischemia-reperfusion injury than other organs. Tissue specific post-translational modifications of cytochrome c (Cytc) are involved in ischemia-reperfusion injury by regulating mitochondrial respiration and apoptosis....
18.
Weigert R, Hetzel S, Bailly N, Haggerty C, Ilik I, Yung P, et al.
Nat Cell Biol
. 2023 Apr;
25(4):579-591.
PMID: 37024684
DNA and Histone 3 Lysine 27 methylation typically function as repressive modifications and operate within distinct genomic compartments. In mammals, the majority of the genome is kept in a DNA...
19.
Landshammer A, Bolondi A, Kretzmer H, Much C, Buschow R, Rose A, et al.
Elife
. 2023 Jan;
12.
PMID: 36719724
Long non-coding RNAs (lncRNAs) have emerged as fundamental regulators in various biological processes, including embryonic development and cellular differentiation. Despite much progress over the past decade, the genome-wide annotation of...
20.
Shahryari M, Keller S, Meierhofer D, Wallach I, Safraou Y, Guo J, et al.
Front Bioeng Biotechnol
. 2023 Jan;
10:1042711.
PMID: 36698634
The liver is the central metabolic organ. It constantly adapts its metabolic capacity to current physiological requirements. However, the relationship between tissue structure and hepatic function is incompletely understood; this...