David McMillen
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Explore the profile of David McMillen including associated specialties, affiliations and a list of published articles.
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8
Citations
523
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Recent Articles
1.
Duggan A, McMillen D
J Vis Exp
. 2023 Jul;
(196).
PMID: 37427913
Lactobacillus were an incredibly large, diverse genus of bacteria comprising 261 species, several of which were commensal strains with the potential for use as a chassis for synthetic biological endeavors...
2.
Ang J, Ingalls B, McMillen D
Methods Enzymol
. 2010 Dec;
487:279-317.
PMID: 21187229
A key aspect of the behavior of any system is the timescale on which it operates: when inputs change, do responses take milliseconds, seconds, minutes, hours, days, months? Does the...
3.
Guido N, Wang X, Adalsteinsson D, McMillen D, Hasty J, Cantor C, et al.
Nature
. 2006 Feb;
439(7078):856-60.
PMID: 16482159
The ability to construct synthetic gene networks enables experimental investigations of deliberately simplified systems that can be compared to qualitative and quantitative models. If simple, well-characterized modules can be coupled...
4.
Adalsteinsson D, McMillen D, Elston T
BMC Bioinformatics
. 2004 Apr;
5:24.
PMID: 15113411
Background: Intrinsic fluctuations due to the stochastic nature of biochemical reactions can have large effects on the response of biochemical networks. This is particularly true for pathways that involve transcriptional...
5.
McMillen D, Kopell N
J Comput Neurosci
. 2003 Sep;
15(2):143-57.
PMID: 14512745
Rhythmic, synchronous firing of groups of neurons is associated with behaviorally relevant states, and it is thus of interest to understand the mechanisms by which synchronization may be achieved. In...
6.
Hasty J, Isaacs F, Dolnik M, McMillen D, Collins J
Chaos
. 2003 Jun;
11(1):207-220.
PMID: 12779454
The engineered control of cellular function through the design of synthetic genetic networks is becoming plausible. Here we show how a naturally occurring network can be used as a parts...
7.
Hasty J, McMillen D, Collins J
Nature
. 2002 Nov;
420(6912):224-30.
PMID: 12432407
A central focus of postgenomic research will be to understand how cellular phenomena arise from the connectivity of genes and proteins. This connectivity generates molecular network diagrams that resemble complex...
8.
McMillen D, Kopell N, Hasty J, Collins J
Proc Natl Acad Sci U S A
. 2002 Jan;
99(2):679-84.
PMID: 11805323
The ability to design and construct synthetic gene regulatory networks offers the prospect of studying issues related to cellular function in a simplified context; such networks also have many potential...