David Margulies
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Explore the profile of David Margulies including associated specialties, affiliations and a list of published articles.
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Citations
534
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Recent Articles
1.
Halfin O, Avram L, Albeck S, Unger T, Motiei L, Margulies D
Chem Sci
. 2024 Aug;
PMID: 39149216
As a result of calcium ion binding, the calcium-dependent regulatory protein calmodulin (CaM) undergoes a conformational change, enabling it to bind to and activate a variety of enzymes. However, the...
2.
Suss O, Halfin O, Porat Z, Sirkis Y, Motiei L, Margulies D
Angew Chem Int Ed Engl
. 2023 Nov;
63(7):e202312461.
PMID: 38010219
Drawing inspiration from allosteric signaling enzymes, whose catalytic and regulatory units are non-covalently linked, we have devised a method to establish unnatural, effector-mediated enzyme activation within native cells. The feasibility...
3.
Winer L, Motiei L, Margulies D
Bioconjug Chem
. 2023 Aug;
34(9):1509-1522.
PMID: 37556353
The unfathomable role that fluorescence detection plays in the life sciences has prompted the development of countless fluorescent labels, sensors, and analytical techniques that can be used to detect and...
4.
Motiei L, Margulies D
Acc Chem Res
. 2023 Jun;
56(13):1803-1814.
PMID: 37335975
Fluorescent molecular sensors, often referred to as "turn-on" or "turn-off" fluorescent probes, are synthetic agents that change their fluorescence signal in response to analyte binding. Although these sensors have become...
5.
Prasad P, Eizenshtadt N, Goliand I, Fellus-Alyagor L, Oren R, Golani O, et al.
Mater Today Bio
. 2023 Jun;
20:100669.
PMID: 37334185
Common methods to label cell surface proteins (CSPs) involve the use of fluorescently modified antibodies (Abs) or small-molecule-based ligands. However, optimizing the labeling efficiency of such systems, for example, by...
6.
Weinstein J, Marti-Gomez C, Lipsh-Sokolik R, Hoch S, Liebermann D, Nevo R, et al.
Nat Commun
. 2023 May;
14(1):2890.
PMID: 37210560
Mutations in a protein active site can lead to dramatic and useful changes in protein activity. The active site, however, is sensitive to mutations due to a high density of...
7.
Prasad P, Motiei L, Margulies D
Small
. 2023 Jan;
19(13):e2206136.
PMID: 36670059
The advent of DNA nanotechnology has revolutionized the way DNA has been perceived. Rather than considering it as the genetic material alone, DNA has emerged as a versatile synthetic scaffold...
8.
Williams L, Gerber D, Elder A, Tseng W, Baru V, Delaney-Busch N, et al.
Mol Ther Nucleic Acids
. 2022 Jul;
29:189-203.
PMID: 35860385
Mutations in the gene are the cause of an ultra-rare neurological disorder characterized by intellectual disability, impaired speech, motor delay, and hypotonia evolving to spasticity, central sleep apnea, and premature...
9.
Hatai J, Altay Y, Sood A, Kiani A, Eleveld M, Motiei L, et al.
J Am Chem Soc
. 2022 Feb;
144(7):3074-3082.
PMID: 35139307
Self-replicating systems play an important role in research on the synthesis and origin of life. Monitoring of these systems has mostly relied on techniques such as NMR or chromatography, which...
10.
Suss O, Motiei L, Margulies D
Molecules
. 2021 Jun;
26(9).
PMID: 34068759
Fluorescent sensing of biomolecules has served as a revolutionary tool for studying and better understanding various biological systems. Therefore, it has become increasingly important to identify fluorescent building blocks that...