David M Smith
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Explore the profile of David M Smith including associated specialties, affiliations and a list of published articles.
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278
Citations
7471
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Recent Articles
21.
Fu H, Vuononvirta J, Fanti S, Bonacina F, dAmati A, Wang G, et al.
Nat Metab
. 2023 Oct;
5(11):1969-1985.
PMID: 37884694
T cell activation is associated with a profound and rapid metabolic response to meet increased energy demands for cell division, differentiation and development of effector function. Glucose uptake and engagement...
22.
Baer A, Wawra S, Bielmeier K, Uttinger M, Smith D, Peukert W, et al.
Small
. 2023 Oct;
20(6):e2304670.
PMID: 37806757
The Stokes-Einstein-Sutherland (SES) equation is at the foundation of statistical physics, relating a particle's diffusion coefficient and size with the fluid viscosity, temperature, and the boundary condition for the particle-solvent...
23.
Thomas T, Salcedo-Tacuma D, Smith D
Biomolecules
. 2023 Sep;
13(9).
PMID: 37759726
The proteasome, a complex multi-catalytic protease machinery, orchestrates the protein degradation essential for maintaining cellular homeostasis, and its dysregulation also underlies many different types of diseases. Its function is regulated...
24.
Farr A, Smith D, Pesa J, Cao Z
J Health Econ Outcomes Res
. 2023 Sep;
2(1):29-40.
PMID: 37664086
For patients with schizophrenia, the transition from inpatient hospitalization to outpatient care presents a challenge to providing continuous care. Lapses in care during this time period can result in poor...
25.
Livraghi M, Pahi S, Nowakowski P, Smith D, Wick C, Smith A
J Phys Chem B
. 2023 Aug;
127(35):7648-7662.
PMID: 37616478
Accurate molecular modeling of the physical and chemical behavior of highly cross-linked epoxy resins at the atomistic scale is important for the design of new property-optimized materials. However, a systematic...
26.
Hollring K, Baer A, Vucemilovic-Alagic N, Smith D, Smith A
J Colloid Interface Sci
. 2023 Jul;
650(Pt B):1930-1940.
PMID: 37517192
Hypothesis: Diffusion in confinement is an important fundamental problem with significant implications for applications of supported liquid phases. However, resolving the spatially dependent diffusion coefficient, parallel and perpendicular to interfaces,...
27.
Chuah J, Rexroad M, Smith D
Commun Biol
. 2023 Jul;
6(1):733.
PMID: 37454196
Considering the link between neurodegenerative diseases and impaired proteasome function, and the neuro-protective impact of enhanced proteasome activity in animal models, it's crucial to understand proteasome activation mechanisms. A hydrophobic-tyrosine-any...
28.
Chuah J, Thibaudeau T, Smith D
Commun Biol
. 2023 Jul;
6(1):725.
PMID: 37452144
The implication of reduced proteasomal function in neurodegenerative diseases combined with studies showing the protective effects of increasing proteasome activity in animal models highlight the need to understand the capacity...
29.
Gong G, Bilanges B, Allsop B, Masson G, Roberton V, Askwith T, et al.
Nature
. 2023 May;
618(7963):159-168.
PMID: 37225977
Harnessing the potential beneficial effects of kinase signalling through the generation of direct kinase activators remains an underexplored area of drug development. This also applies to the PI3K signalling pathway,...
30.
Freitag J, Moser C, Belay R, Altattan B, Grasse N, Pothineni B, et al.
Nanoscale
. 2023 Apr;
15(17):7608-7624.
PMID: 37042085
In many applications such as diagnostics and therapy development, small peptide fragments consisting of only a few amino acids are often attractive alternatives to bulky proteins. This is due to...