David M Smith
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Explore the profile of David M Smith including associated specialties, affiliations and a list of published articles.
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278
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7471
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Recent Articles
11.
Subramanian D, Miller A, Smith D
bioRxiv
. 2024 Jul;
PMID: 38948695
The retrosplenial cortex (RSC) plays an important role in spatial cognition. RSC neurons exhibit a variety of spatial firing patterns and lesion studies have found that the RSC is necessary...
12.
Salcedo-Tacuma D, Howells G, McHose C, Gutierrez-Diaz A, Schupp J, Smith D
bioRxiv
. 2024 Jun;
PMID: 38895466
The proteasome plays a crucial role in cellular homeostasis by degrading misfolded, damaged, or unnecessary proteins. Understanding the regulatory mechanisms of proteasome activity is vital, particularly the interaction with activators...
13.
Chuah J, Daugherty M, Smith D
bioRxiv
. 2024 Jun;
PMID: 38826226
Enhancing proteasome function has been a long-standing but challenging target of interest for the potential treatment of neurodegenerative diseases, emphasizing the importance of understanding proteasome activation mechanisms. Most proteasome activator...
14.
Subramanian D, Miller A, Smith D
Hippocampus
. 2024 May;
34(7):357-377.
PMID: 38770779
The hippocampus (HPC) and retrosplenial cortex (RSC) are key components of the brain's memory and navigation systems. Lesions of either region produce profound deficits in spatial cognition and HPC neurons...
15.
Gantenberg J, van Aalst R, Reddy Bhuma M, Limone B, Diakun D, Smith D, et al.
J Pediatric Infect Dis Soc
. 2024 May;
13(6):317-327.
PMID: 38738450
Background: Respiratory syncytial virus (RSV) is a major cause of morbidity and mortality among US infants. A child's calendar birth month determines their age at first exposure(s) to RSV. We...
16.
Salcedo-Tacuma D, Asad N, Howells G, Anderson R, Smith D
bioRxiv
. 2024 Apr;
PMID: 38617285
Proteasome dysfunction is implicated in the pathogenesis of neurodegenerative diseases and age-related proteinopathies. Using a model, we demonstrate that 20S proteasome hyperactivation, facilitated by 20S gate-opening, accelerates the targeting of...
17.
Subramanian D, Smith D
bioRxiv
. 2024 Mar;
PMID: 38464235
The retrosplenial cortex (RSC) is a key component of the brain's memory systems, with anatomical connections to the hippocampus, anterior thalamus, and entorhinal cortex. This circuit has been implicated in...
18.
Heitmann T, Liao G, de Leon P, Ernst G, Buchler I, Wei H, et al.
ACS Med Chem Lett
. 2023 Dec;
14(12):1760-1766.
PMID: 38116421
A high-throughput fragment-based screen has been employed to discover a series of quinazolinone inositol hexakisphosphate kinase (IP6K) inhibitors. IP6Ks have been studied for their role in glucose homeostasis, metabolic disease,...
19.
Hollring K, Baer A, Vucemilovic-Alagic N, Smith D, Smith A
J Colloid Interface Sci
. 2023 Dec;
657:272-289.
PMID: 38043229
Hypothesis: Diffusion in confinement is an important fundamental problem with significant implications for applications of supported liquid phases. However, resolving the spatially dependent diffusion coefficient, parallel and perpendicular to interfaces,...
20.
Smith D
J Urban Health
. 2023 Dec;
100(6):1224-1233.
PMID: 38038818
This article uses ethnographic and qualitative research to explore the health implications and social responses of a low-income neighborhood in Southeast England, to more than a decade of austerity policies...