David M Chenoweth
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Explore the profile of David M Chenoweth including associated specialties, affiliations and a list of published articles.
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83
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1030
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Recent Articles
1.
Jin P, Rafizadeh D, Zhao H, Chenoweth D
Chembiochem
. 2025 Feb;
:e202400834.
PMID: 40021488
Creating stabilized peptide mimics of the collagen triple helix is challenging, especially for collagen heterotrimers. Interstrand sidechain crosslinking offers a useful approach, though this strategy can suffer from destabilizing structural...
2.
Bareghamyan A, Deng C, Daoudi S, Yadav S, Lu X, Zhang W, et al.
bioRxiv
. 2025 Feb;
PMID: 39974889
Recombinant optogenetic and chemogenetic proteins are potent tools for manipulating neuronal activity and controlling neural circuit function. However, there are few analogous tools for manipulating the structure of neural circuits....
3.
Zhao R, Wivagg A, Lackner R, Salsman J, Dellaire G, Matunis M, et al.
bioRxiv
. 2025 Feb;
PMID: 39896638
Many cancers use an alternative lengthening of telomeres (ALT) pathway for telomere maintenance. ALT telomeric DNA synthesis occurs in ALT telomere-associated PML bodies (APBs). However, the mechanisms by which APBs...
4.
Tu W, Theisen R, Jin P, Chenoweth D, Patel A, Good M
bioRxiv
. 2024 Dec;
PMID: 39651133
Cells contain membrane-bound and membraneless organelles that operate as spatially distinct biochemical niches. However, these subcellular reaction centers lose fidelity with aging and as a result of disease. A grand...
5.
Kim N, Choi M, Suh S, Chenoweth D
Chem Rev
. 2024 Oct;
124(20):11435-11522.
PMID: 39383091
Arynes hold significance for the efficient fusion of (hetero) arenes with diverse substrates, advancing the construction of complex molecular frameworks. Employing multiple equivalents of arynes is particularly effective in the...
6.
Deng C, Lan Y, Chen G, Ekeabu C, Chung M, Lampson M, et al.
bioRxiv
. 2024 Sep;
PMID: 39314350
Traditional pharmacology has limited control of drug activity and localization in space and time. Herein, we described an approach for kinase regulation using conditional localization pharmacology (CLP), where an inactive...
7.
Chen G, Deng C, Chenoweth D, Lampson M
bioRxiv
. 2024 Sep;
PMID: 39257822
Anaphase chromosome segregation depends on forces exerted by spindle microtubules. In the current model, forces on chromosomes are mediated through the spindle poles: sliding of antiparallel microtubules in the central...
8.
Merigliano C, Ryu T, See C, Caridi C, Li X, Butova N, et al.
bioRxiv
. 2024 Jul;
PMID: 39071440
Phase separation forms membraneless compartments in the nuclei, including by establishing heterochromatin "domains" and repair foci. Pericentromeric heterochromatin mostly comprises repeated sequences prone to aberrant recombination, and "safe" homologous recombination...
9.
Zhao R, Xu M, Yu X, Wondisford A, Lackner R, Salsman J, et al.
Genes Dev
. 2024 Jul;
38(13-14):614-630.
PMID: 39038850
The alternative lengthening of telomeres (ALT) pathway maintains telomere length in a significant fraction of cancers that are associated with poor clinical outcomes. A better understanding of ALT mechanisms is...
10.
Ahn J, Johnny C, Chenoweth D
Bioconjug Chem
. 2024 Jun;
35(7):890-896.
PMID: 38913976
Investigating cholesterol trafficking pathways continues to be of significant scientific interest owing to its homeostasis being associated with several debilitating cardiovascular and neurodegenerative diseases including atherosclerosis, Niemann-Pick's disease, Alzheimer's disease,...