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David Labaree

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Recent Articles
11.
Gallezot J, Nabulsi N, Henry S, Pracitto R, Planeta B, Ropchan J, et al.
J Nucl Med . 2019 Mar; 60(8):1140-1146. PMID: 30877174
The 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme converts cortisone to cortisol and participates in the regulation of glucocorticoid levels in tissues. 11β-HSD1 is expressed in the liver, kidney, adipose tissue,...
12.
Hanson R, McCaskill E, Hua E, Tongcharoensirikul P, Dilis R, Silver J, et al.
Steroids . 2019 Feb; 144:15-20. PMID: 30738075
A series consisting of substituted benzoylbenzamide derivatives of 17α-E-vinyl estradiol 6a-i and 7a-d was prepared in good overall yields from the corresponding novel iodinated benzoylbenzamide precursors using Pd(0)-catalyzed Stille coupling....
13.
Nabulsi N, Holden D, Zheng M, Bois F, Lin S, Najafzadeh S, et al.
J Nucl Med . 2019 Feb; 60(8):1147-1153. PMID: 30733324
The M muscarinic acetylcholine receptor (mAChR) plays an important role in learning and memory, and therefore is a target for development of drugs for treatment of cognitive impairments in Alzheimer...
14.
Li S, Zheng M, Naganawa M, Kim S, Gao H, Kapinos M, et al.
J Nucl Med . 2019 Jan; 60(7):1023-1030. PMID: 30630942
Studies have shown κ-opioid receptor (KOR) abnormalities in addictive disorders, other central nervous system diseases, and Alzheimer's disease. We have developed the first set of agonist C-GR103545 and antagonist C-LY2795050...
15.
Li S, Cai Z, Wu X, Holden D, Pracitto R, Kapinos M, et al.
ACS Chem Neurosci . 2018 Nov; 10(3):1544-1554. PMID: 30396272
Structural disruption and alterations of synapses are associated with many brain disorders including Alzheimer's disease, epilepsy, depression, and schizophrenia. We have previously developed the PET radiotracer C-UCB-J for imaging and...
16.
Naganawa M, Lim K, Nabulsi N, Lin S, Labaree D, Ropchan J, et al.
Mol Imaging Biol . 2018 Feb; 20(5):835-845. PMID: 29468404
Purpose: Previous studies demonstrated the utility of [F]fluoropropyl-(+)-dihydrotetrabenazine ([F]FP-(+)-DTBZ) as a positron emission tomography (PET) radiotracer for the vesicular monoamine transporter type 2 (VMAT2) to quantify beta cell mass in...
17.
Gallezot J, Nabulsi N, Holden D, Lin S, Labaree D, Ropchan J, et al.
J Nucl Med . 2017 Sep; 59(2):327-333. PMID: 28864634
The lysophosphatidic acid receptor type 1 (LPA1) is 1 of 6 known receptors of the extracellular signaling molecule lysophosphatidic acid. It mediates effects such as cell proliferation, migration, and differentiation....
18.
Li S, Cai Z, Zheng M, Holden D, Naganawa M, Lin S, et al.
J Nucl Med . 2017 Jul; 59(1):140-146. PMID: 28747521
The κ-opioid receptor (KOR) has been implicated in depression, addictions, and other central nervous system disorders and, thus, is an important target for drug development. We previously developed several C-labeled...
19.
Baldassarri S, Hillmer A, Anderson J, Jatlow P, Nabulsi N, Labaree D, et al.
Nicotine Tob Res . 2017 May; 20(4):425-433. PMID: 28460123
Background: Electronic cigarettes (ECs) can influence nicotine addiction by delivering aerosolized nicotine. We investigated if nicotine from ECs is delivered to the brain β2*-nicotinic acetylcholine receptors (β2*-nAChR) and how this...
20.
Hillmer A, Li S, Zheng M, Scheunemann M, Lin S, Nabulsi N, et al.
Eur J Nucl Med Mol Imaging . 2017 Jan; 44(6):1042-1050. PMID: 28120003
Purpose: The α nicotinic acetylcholine receptor (nAChR) is implicated in many neuropsychiatric disorders, making it an important target for positron emission tomography (PET) imaging. The first aim of this work...