David L Schonberg
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Explore the profile of David L Schonberg including associated specialties, affiliations and a list of published articles.
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13
Citations
549
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Recent Articles
1.
Rosager A, Sorensen M, Dahlrot R, Hansen S, Schonberg D, Rich J, et al.
PLoS One
. 2017 Aug;
12(8):e0182954.
PMID: 28837569
Astrocytic brain tumors are the most frequent primary brain tumors. Treatment with radio- and chemotherapy has increased survival making prognostic biomarkers increasingly important. The aim of the present study was...
2.
Schonberg D, Miller T, Wu Q, Flavahan W, Das N, Hale J, et al.
Cancer Cell
. 2015 Oct;
28(4):441-455.
PMID: 26461092
Glioblastomas display hierarchies with self-renewing cancer stem-like cells (CSCs). RNA sequencing and enhancer mapping revealed regulatory programs unique to CSCs causing upregulation of the iron transporter transferrin, the top differentially...
3.
Schonberg D, Bao S, Rich J
Nat Genet
. 2013 Sep;
45(10):1105-7.
PMID: 24071842
Identifying genomic alterations in cancer does not guarantee therapeutic benefit. A new study combining DNA and RNA sequencing with functional validation uncovers new genetic driver alterations in glioblastoma with potential...
4.
Schonberg D, Venere M, Rich J
Proc Natl Acad Sci U S A
. 2013 Aug;
110(36):14510-1.
PMID: 23969832
No abstract available.
5.
Schonberg D, Lubelski D, Miller T, Rich J
Mol Aspects Med
. 2013 Jul;
39:82-101.
PMID: 23831316
Glioblastoma (GBM) is the most prevalent primary brain tumor and ranks among the most lethal of human cancers with conventional therapy offering only palliation. Great strides have been made in...
6.
Sauerbeck A, Schonberg D, Laws J, McTigue D
Exp Neurol
. 2013 May;
248:53-61.
PMID: 23712107
Excess iron accumulation within the spinal cord is thought to exacerbate tissue damage and limit functional recovery after traumatic spinal cord injury (SCI). An optimal treatment to reverse or prevent...
7.
8.
Schonberg D, Goldstein E, Sahinkaya F, Wei P, Popovich P, McTigue D
J Neurosci
. 2012 Apr;
32(16):5374-84.
PMID: 22514302
Injured CNS tissue often contains elevated iron and its storage protein ferritin, which may exacerbate tissue damage through pro-oxidative mechanisms. Therefore, therapeutic studies often target iron reduction as a neuroprotective...
9.
Gensel J, Schonberg D, Alexander J, McTigue D, Popovich P
J Neurosci Methods
. 2010 May;
190(1):71-9.
PMID: 20438758
There is a need to develop therapies that promote growth or remyelination of mammalian CNS axons. Although the feasibility of pre-clinical treatment strategies should be tested in animal models, in...
10.
Schonberg D, McTigue D
Exp Neurol
. 2009 Apr;
218(1):64-74.
PMID: 19374902
Progenitor proliferation and differentiation are necessary for oligodendrocyte replacement. Previously, we showed that intraspinal activation of microglia and macrophages with the TLR4 agonist lipopolysaccharide (LPS) induced robust oligodendrocyte genesis. In...