David L Ebenezer
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Explore the profile of David L Ebenezer including associated specialties, affiliations and a list of published articles.
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Citations
539
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Recent Articles
1.
Kaufman J, Nabozny G, Tran-Manh C, Liebel C, Zhou X, Daley L, et al.
Rheumatology (Oxford)
. 2025 Feb;
PMID: 39985455
Objectives: The soluble guanylate cyclase (sGC) stimulator riociguat is approved for the treatment of pulmonary arterial hypertension and may have antifibrotic effects. However, in fibrotic tissues, oxidative stress and hypoxia...
2.
Ebenezer D, Ramchandran R, Fu P, Mangio L, Suryadevara V, Ha A, et al.
Cell Biochem Biophys
. 2021 Jun;
79(3):575-592.
PMID: 34085165
Sphingosine-1-phosphate (S1P), a bioactive lipid mediator, is generated from sphingosine by sphingosine kinases (SPHKs) 1 and 2 and is metabolized to ∆2-hexadecenal (∆2-HDE) and ethanolamine phosphate by S1P lyase (S1PL)...
3.
Ha A, Bai T, Ebenezer D, Sethi T, Sudhadevi T, Mangio L, et al.
Thorax
. 2021 Apr;
77(1):47-57.
PMID: 33883249
Introduction: Neonatal lung injury as a consequence of hyperoxia (HO) therapy and ventilator care contribute to the development of bronchopulmonary dysplasia (BPD). Increased expression and activity of lysyl oxidase (LOX),...
4.
Ha A, Sudhadevi T, Ebenezer D, Fu P, Berdyshev E, Ackerman S, et al.
Am J Physiol Lung Cell Mol Physiol
. 2020 Jul;
319(3):L497-L512.
PMID: 32697651
Hyperoxia (HO)-induced lung injury contributes to bronchopulmonary dysplasia (BPD) in preterm newborns. Intractable wheezing seen in BPD survivors is associated with airway remodeling (AWRM). Sphingosine kinase 1 (SPHK1)/sphingosine-1-phosphate (S1P) signaling...
5.
Fu P, Ramchandran R, Shaaya M, Huang L, Ebenezer D, Jiang Y, et al.
J Biol Chem
. 2020 Apr;
295(22):7669-7685.
PMID: 32327488
Increased permeability of vascular lung tissues is a hallmark of acute lung injury and is often caused by edemagenic insults resulting in inflammation. Vascular endothelial (VE)-cadherin undergoes internalization in response...
6.
Ebenezer D, Fu P, Ramchandran R, Ha A, Putherickal V, Sudhadevi T, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2020 Mar;
1865(7):158681.
PMID: 32171908
Long-chain fatty aldehydes are present in low concentrations in mammalian cells and serve as intermediates in the interconversion between fatty acids and fatty alcohols. The long-chain fatty aldehydes are generated...
7.
Sudhadevi T, Ha A, Ebenezer D, Fu P, Putherickal V, Natarajan V, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2020 Mar;
1865(7):158685.
PMID: 32169655
Bronchopulmonary dysplasia (BPD) is a devastating chronic neonatal lung disease leading to serious adverse consequences. Nearly 15 million babies are born preterm accounting for >1 in 10 births globally. The...
8.
Ebenezer D, Fu P, Krishnan Y, Maienschein-Cline M, Hu H, Jung S, et al.
BMC Genomics
. 2019 Dec;
20(1):984.
PMID: 31842752
Background: Pseudomonas aeruginosa (PA) is an opportunistic Gram-negative bacterium that causes serious life threatening and nosocomial infections including pneumonia. PA has the ability to alter host genome to facilitate its...
9.
Ebenezer D, Berdyshev E, Bronova I, Liu Y, Tiruppathi C, Komarova Y, et al.
Thorax
. 2019 Feb;
74(6):579-591.
PMID: 30723184
Introduction: Dysregulated sphingolipid metabolism has been implicated in the pathogenesis of various pulmonary disorders. Nuclear sphingosine-1-phosphate (S1P) has been shown to regulate histone acetylation, and therefore could mediate pro-inflammatory genes...
10.
Fu P, Ebenezer D, Ha A, Suryadevara V, Harijith A, Natarajan V
J Cell Biochem
. 2018 Jan;
119(8):6337-6353.
PMID: 29377310
Phospholipids, sphingolipids, and cholesterol are integral components of eukaryotic cell organelles, including the nucleus. Recent evidence shows characteristic features of nuclear lipid composition and signaling, which are distinct from that...