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David Keeling

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Articles 63
Citations 1374
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Recent Articles
11.
Keeling D
Lancet Haematol . 2018 Jan; 5(1):e4-e5. PMID: 29304324
No abstract available.
12.
Jackson S, Candia A, Delaney S, Floettmann S, Wong C, Campbell J, et al.
Clin Pharmacol Ther . 2017 Nov; 104(2):335-345. PMID: 29134633
Current asthma treatments address symptoms rather than the underlying disease pathophysiology, a better understanding of which has led to the identification of the Th2 high endotype. The activation of Toll-like...
13.
Bell J, Dymond M, Biffen M, Delaney S, Keeling D, Zhang H, et al.
Toxicol Appl Pharmacol . 2017 Nov; 338:9-19. PMID: 29122671
AZD8848 is a TLR7 agonist antedrug developed for administration by inhalation dosing for the treatment of allergic diseases, such as asthma. Allergic asthma is associated with increased levels of Th2...
14.
Roy N, Curry N, Keeling D
Br J Haematol . 2017 Jul; 179(2):182. PMID: 28677841
No abstract available.
15.
Shapiro S, Bhatnagar N, Khan A, Beavis J, Keeling D
Br J Haematol . 2016 Oct; 180(3):457-459. PMID: 27734469
No abstract available.
16.
Keeling D, Tait R, Watson H
Br J Haematol . 2016 Oct; 175(4):602-613. PMID: 27714755
No abstract available.
17.
Crawford F, Andras A, Welch K, Sheares K, Keeling D, Chappell F
Cochrane Database Syst Rev . 2016 Aug; (8):CD010864. PMID: 27494075
Background: Pulmonary embolism (PE) can occur when a thrombus (blood clot) travels through the veins and lodges in the arteries of the lungs, producing an obstruction. People who are thought...
18.
Liljevald M, Rehnberg M, Soderberg M, Ramnegard M, Borjesson J, Luciani D, et al.
Autoimmun Rev . 2016 Aug; 15(11):1062-1070. PMID: 27491564
RORγ is a nuclear hormone receptor which controls polarization of naive CD4 T-cells into proinflammatory Th17 cells. Pharmacological antagonism of RORγ has therapeutic potential for autoimmune diseases; however, this mechanism...
19.
Delaney S, Biffen M, Maltby J, Bell J, Asimus S, Aggarwal A, et al.
BMJ Open Respir Res . 2016 Mar; 3(1):e000113. PMID: 26933507
Background: Many patients with asthma have a T-helper type 2 (Th2) driven inflammation of the lung, whereas toll-like receptor 7 (TLR7) agonists, by inducing type I interferons, inhibit Th2 responses....
20.
Keeling D, Klok F, Le Gal G
Blood Rev . 2015 Aug; 30(1):27-33. PMID: 26239706
Venous thromboembolism is commonly encountered both in the community and the in-patient setting. Despite major advances in diagnosis and treatment, there remain challenges in several clinical areas as a result...