David Jonah Grunwald
Overview
Explore the profile of David Jonah Grunwald including associated specialties, affiliations and a list of published articles.
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14
Citations
916
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Recent Articles
1.
Jurynec M, Bai X, Bisgrove B, Jackson H, Nechiporuk A, Palu R, et al.
Development
. 2019 Dec;
146(24).
PMID: 31784460
Multipotent progenitor populations are necessary for generating diverse tissue types during embryogenesis. We show the RNA polymerase-associated factor 1 complex (Paf1C) is required to maintain multipotent progenitors of the neural...
2.
Hoshijima K, Jurynec M, Shaw D, Jacobi A, Behlke M, Grunwald D
Dev Cell
. 2019 Nov;
51(5):645-657.e4.
PMID: 31708433
Inconsistent activity limits the use of CRISPR-Cas9 in zebrafish. We show supernumerary guanine nucleotides at the 5' ends of single guide RNAs (sgRNAs) account for diminished CRISPR-Cas9 activity in zebrafish...
3.
Jurynec M, Sawitzke A, Beals T, Redd M, Stevens J, Otterud B, et al.
Hum Mol Genet
. 2018 Jun;
27(13):2406.
PMID: 29860498
No abstract available.
4.
Shaw D, Gunther D, Jurynec M, Chagovetz A, Ritchie E, Grunwald D
Dev Cell
. 2018 May;
45(4):512-525.e5.
PMID: 29754802
Graded Shh signaling across fields of precursor cells coordinates patterns of gene expression, differentiation, and morphogenetic behavior as precursors form complex structures, such as the nervous system, the limbs, and...
5.
Jurynec M, Sawitzke A, Beals T, Redd M, Stevens J, Otterud B, et al.
Hum Mol Genet
. 2018 Apr;
27(13):2383-2391.
PMID: 29659823
Osteoarthritis (OA) is a common debilitating disease characterized by abnormal remodeling of the cartilage and bone of the articular joint. Ameliorating therapeutics are lacking due to limited understanding of the...
6.
Hoshijima K, Jurynec M, Grunwald D
Dev Cell
. 2016 Mar;
36(6):654-67.
PMID: 27003937
We present simple and efficient methods for creating heritable modifications of the zebrafish genome. Precisely modified alleles are generated by homologous recombination between the host genome and dsDNA donor molecules,...
7.
Hu R, Wallace J, Dahlem T, Grunwald D, OConnell R
PLoS One
. 2013 May;
8(5):e63074.
PMID: 23667577
MicroRNAs (miRNAs) have quickly emerged as important regulators of mammalian physiology owing to their precise control over the expression of critical protein coding genes. Despite significant progress in our understanding...
8.
9.
Dahlem T, Hoshijima K, Jurynec M, Gunther D, Starker C, Locke A, et al.
PLoS Genet
. 2012 Aug;
8(8):e1002861.
PMID: 22916025
The zebrafish is a powerful experimental system for uncovering gene function in vertebrate organisms. Nevertheless, studies in the zebrafish have been limited by the approaches available for eliminating gene function....
10.
Jurynec M, Grunwald D
Dis Model Mech
. 2010 Jul;
3(11-12):733-42.
PMID: 20616095
SH2-domain-containing inositol phosphatase 2 (SHIP2) belongs to a small family of phosphoinositide 5-phosphatases that help terminate intracellular signaling initiated by activated receptor tyrosine kinases. Mammalian SHIP2 is viewed primarily as...