David J Peeler
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Explore the profile of David J Peeler including associated specialties, affiliations and a list of published articles.
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18
Citations
796
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Recent Articles
1.
Peeler D, Sun R, Kutahya C, Peschke P, Zhou K, Brachi G, et al.
Adv Mater
. 2025 Feb;
:e2417290.
PMID: 40018867
Two-photon polymerization (2PP) 3D printing enables top-down biomaterial synthesis with nanoscale spatial resolution for de novo design of monodisperse injectable drug delivery systems. Spatiotemporal Controlled Release Inks of Biocompatible polyEsters...
2.
Chen K, Najer A, Charchar P, Saunders C, Thanapongpibul C, Klockner A, et al.
Nat Commun
. 2024 Nov;
15(1):10321.
PMID: 39609415
Staphylococcus aureus is a leading cause of nosocomial implant-associated infections, causing significant morbidity and mortality, underscoring the need for rapid, non-invasive, and cost-effective diagnostics. Here, we optimise the synthesis of...
3.
Thanapongpibul C, Rifaie-Graham O, Ojansivu M, Najer A, Kim H, Bakker S, et al.
Adv Mater
. 2024 Oct;
36(49):e2408000.
PMID: 39417762
Efficient delivery of therapeutic proteins and vaccine antigens to intracellular targets is challenging due to generally poor cell membrane permeation and endolysosomal entrapment causing degradation. Herein, these challenges are addressed...
4.
Barbieri B, Peeler D, Samnuan K, Day S, Hu K, Sallah H, et al.
J Control Release
. 2024 Aug;
374:280-292.
PMID: 39142355
Lipid nanoparticle (LNP) formulation plays a vital role in RNA vaccine delivery. However, further optimisation of self-amplifying RNA (saRNA) vaccine formulation could help enhance seroconversion rates in humans and improve...
5.
Sun R, Song X, Zhou K, Zuo Y, Wang R, Rifaie-Graham O, et al.
Adv Mater
. 2022 Dec;
35(13):e2207791.
PMID: 36502366
Microrobots can provide spatiotemporally well-controlled cargo delivery that can improve therapeutic efficiency compared to conventional drug delivery strategies. Robust microfabrication methods to expand the variety of materials or cargoes that...
6.
Baldassi D, Ambike S, Feuerherd M, Cheng C, Peeler D, Feldmann D, et al.
J Control Release
. 2022 Apr;
345:661-674.
PMID: 35364120
SARS-CoV-2 has been the cause of a global pandemic since 2019 and remains a medical urgency. siRNA-based therapies are a promising strategy to fight viral infections. By targeting a specific...
7.
Lv S, Song K, Yen A, Peeler D, Nguyen D, Olshefsky A, et al.
Adv Healthc Mater
. 2021 Oct;
11(9):e2101651.
PMID: 34706166
Peptide-based cancer vaccines offer production and safety advantages but have had limited clinical success due to their intrinsic instability, rapid clearance, and low cellular uptake. Nanoparticle-based delivery vehicles can improve...
8.
Sylvestre M, Lv S, Yang L, Luera N, Peeler D, Chen B, et al.
J Control Release
. 2021 Jan;
331:142-153.
PMID: 33444669
The generation of anti-PEG antibodies in response to PEGylated proteins, peptides, and carriers significantly limits their clinical applicability. IgM antibodies mediate the clearance of these therapeutics upon repeat injection, resulting...
9.
Lee J, Zhao T, Peeler D, Lee D, Pichon T, Li D, et al.
Soft Matter
. 2020 Apr;
16(15):3762-3768.
PMID: 32239011
Cell therapy for spinal cord injuries offers the possibility of replacing lost cells after trauma to the central nervous system (CNS). In preclinical studies, synthetic hydrogels are often co-delivered to...
10.
Peeler D, Luera N, Horner P, Pun S, Sellers D
J Control Release
. 2020 Mar;
322:149-156.
PMID: 32198024
Traumatic brain injury (TBI) is largely non-preventable and often kills or permanently disables its victims. Because current treatments for TBI merely ameliorate secondary effects of the initial injury like swelling...