David J McKean
Overview
Explore the profile of David J McKean including associated specialties, affiliations and a list of published articles.
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9
Citations
349
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Recent Articles
1.
Rizza S, Tangalos E, McClees M, Strausbauch M, Targonski P, McKean D, et al.
Front Biosci
. 2007 Nov;
13:1605-9.
PMID: 17981652
Although patients treated with HIV protease inhibitor (PI) containing regimens manifest increases in naïve T cell number, it is unclear whether this is due to reduction in viral replication or...
2.
Graham D, Bell M, Huntoon C, Griffin M, Tai X, Singer A, et al.
J Immunol
. 2006 Oct;
177(9):6098-107.
PMID: 17056536
The differentiation of double-positive (DP) CD4(+)CD8(+) thymocytes to single-positive CD4(+) or CD8(+) T cells is regulated by signals that are initiated by coengagement of the Ag (TCR) and costimulatory receptors....
3.
Graham D, Bell M, McCausland M, Huntoon C, van Deursen J, Faubion W, et al.
J Immunol
. 2005 Dec;
176(1):291-300.
PMID: 16365421
Signaling lymphocyte activation molecule (SLAM) family receptors are critically involved in modulating innate and adaptive immune responses. Several SLAM family receptors have been shown to interact with the adaptor molecule...
4.
Graham D, Bell M, Huntoon C, Weaver J, Hawley N, Badley A, et al.
AIDS
. 2005 Sep;
19(14):1467-72.
PMID: 16135899
Objective: To determine the effects of antiretroviral therapy on thymic output independent of HIV infection. Methods: Thymic output was evaluated by quantifying signal joint T-cell receptor (TCR) recombination excision circles...
5.
Gomez T, Hamann M, McCarney S, Savoy D, Lubking C, Heldebrant M, et al.
Nat Immunol
. 2005 Feb;
6(3):261-70.
PMID: 15696170
Actin reorganization at the immunological synapse is required for the amplification and generation of a functional immune response. Using small interfering RNA, we show here that dynamin 2 (Dyn2), a...
6.
Roden A, Moser M, Tri S, Mercader M, Kuntz S, Dong H, et al.
J Immunol
. 2004 Nov;
173(10):6098-108.
PMID: 15528346
Androgen has been implicated as a negative regulator of host immune function and a factor contributing to the gender dimorphism of autoimmunity. Conversely, androgen deprivation has been suggested to potentiate...
7.
Thomas C, Myhre G, Tschumper R, Sreekumar R, Jelinek D, McKean D, et al.
J Pharmacol Exp Ther
. 2004 Sep;
312(2):537-45.
PMID: 15388785
Azathioprine and 6-mercaptopurine are antimetabolite thiopurine drugs that play important roles in the treatment of leukemia and in the management of conditions requiring immunosuppression, such as inflammatory bowel disease. The...
8.
Dong X, Craig T, Xing N, Bachman L, Paya C, Weih F, et al.
J Biol Chem
. 2003 Sep;
278(49):49378-85.
PMID: 14507914
The nuclear factor-kappaB (NF-kappaB) protein RelB plays a unique role in dendritic cell (DC) function and, as such, is an important regulator of antigen presentation and immune regulation. In this...
9.
Xing N, L Maldonado M, Bachman L, McKean D, Kumar R, Griffin M
Biochem Biophys Res Commun
. 2002 Sep;
297(3):645-52.
PMID: 12270143
Dendritic cell (DC) maturation plays a central role in regulating immunity. We show that glucocorticoid and 1alpha,25(OH)(2)D(3) agonists modulate DCs via distinct and additive signaling pathways. Phenotypic and functional indices...