David J Marcinek
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Explore the profile of David J Marcinek including associated specialties, affiliations and a list of published articles.
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96
Citations
2623
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Recent Articles
1.
Mitchell W, Pharaoh G, Tyshkovskiy A, Campbell M, Marcinek D, Gladyshev V
Aging Cell
. 2025 Mar;
:e70026.
PMID: 40080911
Aging-related decreases in cardiac and skeletal muscle function are strongly associated with various comorbidities. Elamipretide (ELAM), a novel mitochondria-targeted peptide, has demonstrated broad therapeutic efficacy in ameliorating disease conditions associated...
2.
Liu S, Faitg J, Tissot C, Konstantopoulos D, Laws R, Bourdier G, et al.
iScience
. 2025 Mar;
28(2):111814.
PMID: 40034121
Cardiovascular diseases (CVDs) remain the primary cause of global mortality. Nutritional interventions hold promise to reduce CVD risks in an increasingly aging population. However, few nutritional interventions are proven to...
3.
Ahmadi A, Valencia A, Begue G, Norman J, Fan S, Durbin-Johnson B, et al.
Clin J Am Soc Nephrol
. 2025 Jan;
20(3):346-357.
PMID: 39847432
No abstract available.
4.
Campbell M, Sanchez-Contreras M, Sibley B, Keiser P, Ruiz Sanchez C, Mann C, et al.
bioRxiv
. 2024 Dec;
PMID: 39651288
Whether and how podocytes depend on mitochondria across their long post-mitotic lifespan is yet unclear. With limited cell numbers and broad kidney distribution, isolation of podocyte mitochondria typically requires first...
5.
Mitchell W, Pharaoh G, Tyshkovskiy A, Campbell M, Marcinek D, Gladyshev V
bioRxiv
. 2024 Nov;
PMID: 39554099
Aging-related decreases in cardiac and skeletal muscle function are strongly associated with various comorbidities. Elamipretide (ELAM), a novel mitochondrial-targeted peptide, has demonstrated broad therapeutic efficacy in ameliorating disease conditions associated...
6.
Ostrom E, Stuppard R, Mattson-Hughes A, Marcinek D
Free Radic Biol Med
. 2024 Nov;
226():237-250.
PMID: 39551449
Introduction: Skeletal muscle mitochondrial dysfunction is a key characteristic of aging muscle and contributes to age related diseases such as sarcopenia, frailty, and type 2 diabetes. Mitochondrial oxidative stress has...
7.
Ostrom E, Stuppard R, Mattson-Hughes A, Marcinek D
bioRxiv
. 2024 Oct;
PMID: 39386714
Introduction: Skeletal muscle mitochondrial dysfunction is a key characteristic of aging muscle and contributes to age related diseases such as sarcopenia, frailty, and type 2 diabetes. Mitochondrial oxidative distress has...
8.
Mhatre K, Murray J, Flint G, McMillen T, Weber G, Shakeri M, et al.
J Mol Cell Cardiol
. 2024 Sep;
197:150.
PMID: 39294086
No abstract available.
9.
Ahmadi A, Valencia A, Begue G, Norman J, Fan S, Durbin-Johnson B, et al.
medRxiv
. 2024 Sep;
PMID: 39228730
Background: Mitochondria-driven oxidative/redox stress and inflammation play a major role in chronic kidney disease (CKD) pathophysiology. Compounds targeting mitochondrial metabolism may improve mitochondrial function, inflammation, and redox stress; however, there...
10.
Valencia A, Samuelson A, Stuppard R, Marcinek D
JCSM Rapid Commun
. 2024 Jul;
4(2):222-231.
PMID: 39035012
Background: Eccentric contractions induce muscle damage (EIMD) that compromises muscle function. Poor recovery from EIMD has been suggested to be a contributor to the decline in muscle function evident in...