David J Liewehr
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Explore the profile of David J Liewehr including associated specialties, affiliations and a list of published articles.
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83
Citations
3382
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Recent Articles
1.
Lemberg K, Gross A, Sproule L, Liewehr D, Dombi E, Baldwin A, et al.
Pediatr Res
. 2024 Aug;
PMID: 39198589
Background: In children and adolescents/young adults (CAYA) with neurofibromatosis type I (NF1), associations between anthropometric measurements, plexiform neurofibroma (pNF) tumor volume (TV), and treatment history are unknown. Methods: We retrospectively...
2.
Hebron K, Wan X, Roth J, Liewehr D, Sealover N, Frye W, et al.
Clin Cancer Res
. 2022 Nov;
29(2):472-487.
PMID: 36322002
Purpose: PAX-fusion negative rhabdomyosarcoma (FN RMS) is driven by alterations in the RAS/MAP kinase pathway and is partially responsive to MEK inhibition. Overexpression of IGF1R and its ligands is also...
3.
Fuller S, Shafiei A, Venzon D, Liewehr D, Mauda Havanuk M, Ilanchezhian M, et al.
Curr Oncol
. 2021 Dec;
28(6):4357-4366.
PMID: 34898541
Adrenocortical carcinoma (ACC) is a rare malignancy with an overall unfavorable prognosis. Clinicians treating patients with ACC have noted accelerated growth in metastatic liver lesions that requires rapid intervention compared...
4.
Boal L, Glod J, Spencer M, Kasai M, Derdak J, Dombi E, et al.
Clin Cancer Res
. 2020 Sep;
26(23):6112-6121.
PMID: 32943455
Purpose: Simultaneously targeting the tumor and tumor microenvironment may hold promise in treating children with refractory solid tumors. Pexidartinib, an oral inhibitor of tyrosine kinases including colony stimulating factor 1...
5.
Akshintala S, Baldwin A, Liewehr D, Goodwin A, Blakeley J, Gross A, et al.
Neuro Oncol
. 2020 Mar;
22(9):1368-1378.
PMID: 32152628
Background: Understanding the natural history of non-malignant peripheral nerve sheath tumors (PNSTs) in neurofibromatosis type 1 (NF1) is critical to optimal clinical care and the development of meaningful clinical trials....
6.
Komiya T, Memmott R, Blumenthal G, Bernstein W, Ballas M, De Chowdhury R, et al.
Transl Lung Cancer Res
. 2019 Aug;
8(3):247-257.
PMID: 31367538
Background: Single-agent pemetrexed is a treatment for recurrent non-squamous non-small cell lung cancer (NSCLC) that provides limited benefit. Preclinical studies showed promising synergistic effects when the mammalian target of rapamycin...
7.
Salem D, Scott D, McCoy C, Liewehr D, Venzon D, Arons E, et al.
Cytometry B Clin Cytom
. 2019 May;
96(4):275-282.
PMID: 31077558
Background: Hairy cell leukemia (HCL) and hairy cell leukemia variant (HCLv) are rare diseases with overlapping clinicopathological features. Features distinguishing HCL from HCLv include expression of CD25, CD123, CD200, annexin-A1,...
8.
Sissung T, Rajan A, Blumenthal G, Liewehr D, Steinberg S, Berman A, et al.
PLoS One
. 2019 Mar;
14(2):e0212097.
PMID: 30817750
Pharmacogenetics studies have identified several allelic variants with the potential to reduce toxicity and improve treatment outcome. The present study was designed to determine if such findings are reproducible in...
9.
Salem D, Maric I, Yuan C, Liewehr D, Venzon D, Kochenderfer J, et al.
Leuk Res
. 2018 Jul;
71:106-111.
PMID: 30053652
B-cell maturation antigen (BCMA) is expressed by normal and malignant plasma cells and is targeted via anti-BCMA chimeric antigen receptor T-cell therapy (BCMA CAR T-cell therapy) in plasma cell myeloma...
10.
Gross A, Singh G, Akshintala S, Baldwin A, Dombi E, Ukwuani S, et al.
Neuro Oncol
. 2018 May;
20(12):1643-1651.
PMID: 29718344
Background: Plexiform neurofibromas (PN) in neurofibromatosis 1 (NF1) can cause substantial morbidities. Clinical trials targeting PN have recently described decreases in PN volumes. However, no previous study has assessed the...