David J Fear
Overview
Explore the profile of David J Fear including associated specialties, affiliations and a list of published articles.
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19
Citations
549
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Recent Articles
1.
Cutrina-Pons A, De Sa A, Fear D, Gould H, Ramadani F
Immunology
. 2023 Aug;
170(4):483-494.
PMID: 37530226
Phosphoinositide 3-kinase (PI3K) p110δ signalling negatively regulates the production of mouse IgE. However, there are disparities between the mouse and human IgE biology, and the role of PI3K p110δ in...
2.
Moore T, Hossain R, Doores K, Shankar-Hari M, Fear D
Viral Immunol
. 2022 Jul;
35(6):425-436.
PMID: 35857310
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), has resulted in major worldwide disruption and loss of life over the last 2 years. Many research studies...
3.
Tull T, Pitcher M, Guesdon W, Siu J, Lebrero-Fernandez C, Zhao Y, et al.
J Exp Med
. 2021 Feb;
218(4).
PMID: 33538776
B cells emerge from the bone marrow as transitional (TS) B cells that differentiate through T1, T2, and T3 stages to become naive B cells. We have identified a bifurcation...
4.
Sharif H, Acharya S, Dhondalay G, Varricchi G, Krasner-Macleod S, Laisuan W, et al.
J Allergy Clin Immunol
. 2020 Nov;
147(2):663-676.
PMID: 33160969
Background: Allergen-specific immunotherapy is a disease-modifying treatment that induces long-term T-cell tolerance. Objective: We sought to evaluate the role of circulating CXCR5PD-1 T follicular helper (cT) and T follicular regulatory...
5.
Ramadani F, Bowen H, Gould H, Fear D
Front Immunol
. 2019 Mar;
10:402.
PMID: 30915071
IgE is secreted by plasma cells (PCs) and is central to allergic disease. Using an tonsil B cell culture system, which mimics the Th2 responses , we have recently characterized...
6.
Zhao Y, Uduman M, Siu J, Tull T, Sanderson J, Wu Y, et al.
Nat Commun
. 2018 Sep;
9(1):3857.
PMID: 30242242
Human memory B cells and marginal zone (MZ) B cells share common features such as the expression of CD27 and somatic mutations in their IGHV and BCL6 genes, but the...
7.
Recaldin T, Hobson P, Mann E, Ramadani F, Cousins D, Lavender P, et al.
Mol Immunol
. 2018 Aug;
101:419-428.
PMID: 30081328
Class-switch recombination (CSR) is an essential B cell process that alters the isotype of antibody produced by the B cell, tailoring the immune response to the nature of the invading...
8.
Zhang Y, Fear D, Willis-Owen S, Cookson W, Moffatt M
Sci Rep
. 2016 Nov;
6:37988.
PMID: 27897229
Immunoglobulin class switch recombination (CSR) to IgE is a tightly regulated process central to atopic disease. To profile the B-cell transcriptional responses underlying the activation of the germinal centre activities...
9.
Saul L, Ilieva K, Bax H, Karagiannis P, Correa I, Rodriguez-Hernandez I, et al.
Sci Rep
. 2016 Jul;
6:29736.
PMID: 27411958
B cells participate in immune surveillance in human circulation and tissues, including tumors such as melanoma. By contrast, the role of humoral responses in cutaneous immunity is underappreciated. We report...
10.
Fear D
Curr Opin Immunol
. 2013 Nov;
25(5):619-28.
PMID: 24209594
Activation induced cytidine deaminase (AID) plays a central role in the vertebrate adaptive immune response, initiating immunoglobulin (Ig) somatic hypermutation (SHM) and class-switch recombination (CSR). AID converts deoxycytosine (dC) in...