David J Dearlove
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Explore the profile of David J Dearlove including associated specialties, affiliations and a list of published articles.
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12
Citations
104
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Recent Articles
1.
Westcott F, Dearlove D, Hodson L
Atherosclerosis
. 2023 Aug;
394:117237.
PMID: 37633797
The prevalence of metabolic diseases, including type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing. Although invariably associated with obesity, the importance of fat deposition...
2.
Nagarajan S, Livingstone E, Monfeuga T, Lewis L, Ali S, Chandran A, et al.
Metabolism
. 2023 Apr;
144:155563.
PMID: 37088121
Background And Aim: Enhanced hepatic de novo lipogenesis (DNL) has been proposed as an underlying mechanism for the development of NAFLD and insulin resistance. Max-like protein factor X (MLX) acts...
3.
Finnegan S, Dearlove D, Morris P, Freeman D, Sergeant M, Taylor S, et al.
PLoS One
. 2023 Apr;
18(4):e0270721.
PMID: 37083693
Introduction: The sensation of breathlessness is often attributed to perturbations in cardio-pulmonary physiology, leading to changes in afferent signals. New evidence suggests that these signals are interpreted in the light...
4.
Cross E, Dearlove D, Hodson L
Curr Opin Clin Nutr Metab Care
. 2023 Mar;
26(2):65-71.
PMID: 36892956
Purpose Of Review: De novo lipogenesis (DNL) is a metabolic process occurring mainly within the liver, in humans. Insulin is a primary signal for promoting DNL; thus, nutritional state is...
5.
Ketone monoester ingestion increases postexercise serum erythropoietin concentrations in healthy men
Evans E, Walhin J, Hengist A, Betts J, Dearlove D, Gonzalez J
Am J Physiol Endocrinol Metab
. 2022 Nov;
324(1):E56-E61.
PMID: 36449571
Intravenous ketone body infusion can increase erythropoietin (EPO) concentrations, but responses to ketone monoester ingestion postexercise are currently unknown. The purpose of this study was to assess the effect of...
6.
Dearlove D, Hodson L
Curr Opin Clin Nutr Metab Care
. 2022 Jun;
25(4):241-247.
PMID: 35762159
Purpose Of Review: Intrahepatic triglyceride (IHTG) content is determined by substrate flux to, fatty acid synthesis and partitioning within, and triglyceride disposal from the liver. Dysregulation of these processes may...
7.
Dearlove D, Soto Mota A, Hauton D, Pinnick K, Evans R, Miller J, et al.
Physiol Rep
. 2022 May;
10(10):e15309.
PMID: 35614576
Elevating blood ketones may enhance exercise capacity and modulate adaptations to exercise training; however, these effects may depend on whether hyperketonemia is induced endogenously through dietary carbohydrate restriction, or exogenously...
8.
Dearlove D, Holdsworth D, Kirk T, Hodson L, Charidemou E, Kvalheim E, et al.
Front Med (Lausanne)
. 2021 Dec;
8:721673.
PMID: 34901052
In this study, we determined ketone oxidation rates in athletes under metabolic conditions of high and low carbohydrate (CHO) and fat availability. Six healthy male athletes completed 1 h of...
9.
Norwitz N, Dearlove D, Lu M, Clarke K, Dawes H, Hu M
Front Neurosci
. 2020 Oct;
14:584130.
PMID: 33100965
Objectives: Routine exercise is thought to be among the only disease-modifying treatments for Parkinson's disease; however, patients' progressive loss of physical ability limits its application. Therefore, we sought to investigate...
10.
Dearlove D, Harrison O, Hodson L, Jefferson A, Clarke K, Cox P
Med Sci Sports Exerc
. 2020 Sep;
53(3):505-516.
PMID: 32868580
Introduction: Exogenous ketones potentially provide an alternative, energetically advantageous fuel to power exercising skeletal muscle. However, there is limited evidence regarding their relative contribution to energy expenditure during exercise. Furthermore,...