David J Begley
Overview
Explore the profile of David J Begley including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
28
Citations
3462
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Duricki D, Drndarski S, Bernanos M, Wood T, Bosch K, Chen Q, et al.
Ann Neurol
. 2018 Dec;
85(1):32-46.
PMID: 30525223
Objective: Neurotrophin-3 (NT3) plays a key role in the development and function of locomotor circuits including descending serotonergic and corticospinal tract axons and afferents from muscle and skin. We have...
2.
Bigger B, Begley D, Virgintino D, Pshezhetsky A
Mol Genet Metab
. 2018 Aug;
125(4):322-331.
PMID: 30145178
Mucopolysaccharidosis (MPS) disorders are caused by deficiencies in lysosomal enzymes, leading to impaired glycosaminoglycan (GAG) degradation. The resulting GAG accumulation in cells and connective tissues ultimately results in widespread tissue...
3.
Qaiser M, Dolman D, Begley D, Abbott N, Cazacu-Davidescu M, Corol D, et al.
J Neurochem
. 2017 Jul;
142(5):672-685.
PMID: 28665486
Little is known about the origin of the neuroactive steroids dehydroepiandrosterone sulphate (DHEAS) and pregnenolone sulphate (PregS) in the brain or of their subsequent metabolism. Using rat brain perfusion in ...
4.
Scarpa M, Bellettato C, Lampe C, Begley D
Best Pract Res Clin Endocrinol Metab
. 2015 May;
29(2):159-71.
PMID: 25987170
Pharmacological research has always focused on developing new therapeutic strategies capable of modifying a disease's natural history and improving patients' quality of life. Despite recent advances within the fields of...
5.
Preston J, Abbott N, Begley D
Adv Pharmacol
. 2014 Oct;
71:147-63.
PMID: 25307216
The restrictive nature of the blood-brain barrier means that cellular machinery must be in place to deliver macromolecules to the brain. This is achieved by transcytosis which is more complex...
6.
7.
Pontikis C, Davidson C, Walkley S, Platt F, Begley D
J Inherit Metab Dis
. 2013 Feb;
36(3):491-8.
PMID: 23412751
Niemann-Pick type C disease is an inherited autosomal recessive neurodegenerative disorder characterised by the accumulation of unesterified cholesterol and sphingolipids within the endosomal/lysosomal compartments. It has been observed that the...
8.
Muldoon L, Alvarez J, Begley D, Boado R, Del Zoppo G, Doolittle N, et al.
J Cereb Blood Flow Metab
. 2012 Oct;
33(1):13-21.
PMID: 23072749
The brain is in many ways an immunologically and pharmacologically privileged site. The blood-brain barrier (BBB) of the cerebrovascular endothelium and its participation in the complex structure of the neurovascular...
9.
Begley D
Sci Transl Med
. 2012 Aug;
4(147):147fs29.
PMID: 22896674
Gliovascular pathways guide water flow and solute clearance in the brain (Iliff et al., this issue).
10.
Watson C, Dogruel M, Mihoreanu L, Begley D, Weksler B, Couraud P, et al.
Brain Res
. 2011 Dec;
1436:111-21.
PMID: 22200378
Human African trypanosomiasis (HAT) is a parasitic disease affecting sub-Saharan Africa. The parasites are able to traverse the blood-brain barrier (BBB), which marks stage 2 (S2) of the disease. Delivery...