David J Balding
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Explore the profile of David J Balding including associated specialties, affiliations and a list of published articles.
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86
Citations
7198
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Recent Articles
1.
Huang Z, Kelleher J, Chan Y, Balding D
bioRxiv
. 2024 Apr;
PMID: 38559261
Inference of demographic and evolutionary parameters from a sample of genome sequences often proceeds by first inferring identical-by-descent (IBD) genome segments. By exploiting efficient data encoding based on the ancestral...
2.
Grinton B, Robertson E, Fearnley L, Scheffer I, Marson A, OBrien T, et al.
Am J Hum Genet
. 2022 Oct;
109(11):2080-2087.
PMID: 36288729
Genetic epilepsy with febrile seizures plus (GEFS+) is an autosomal dominant familial epilepsy syndrome characterized by distinctive phenotypic heterogeneity within families. The SCN1B c.363C>G (p.Cys121Trp) variant has been identified in...
3.
Caliebe A, Tekola-Ayele F, Darst B, Wang X, Song Y, Gui J, et al.
Genet Epidemiol
. 2022 Jul;
46(7):347-371.
PMID: 35842778
The inclusion of ancestrally diverse participants in genetic studies can lead to new discoveries and is important to ensure equitable health care benefit from research advances. Here, members of the...
4.
Speed D, Kaphle A, Balding D
Bioessays
. 2022 Mar;
44(5):e2100170.
PMID: 35279859
Complex-trait genetics has advanced dramatically through methods to estimate the heritability tagged by SNPs, both genome-wide and in genomic regions of interest such as those defined by functional annotations. The...
5.
Andersen M, Balding D
Genes (Basel)
. 2021 Aug;
12(8).
PMID: 34440383
Y chromosome and mitochondrial DNA profiles have been used as evidence in courts for decades, yet the problem of evaluating the weight of evidence has not been adequately resolved. Both...
6.
Paril J, Balding D, Fournier-Level A
Mol Ecol Resour
. 2021 Jun;
22(1):137-152.
PMID: 34192415
Mapping the genes underlying ecologically relevant traits in natural populations is fundamental to develop a molecular understanding of species adaptation. Current sequencing technologies enable the characterization of a species' genetic...
7.
Balding D, Barsh G, Copenhaver G, Yi C
PLoS Genet
. 2020 Jul;
16(7):e1008950.
PMID: 32667915
No abstract available.
8.
Speed D, Holmes J, Balding D
Nat Genet
. 2020 Mar;
52(4):458-462.
PMID: 32203469
There is currently much debate regarding the best model for how heritability varies across the genome. The authors of GCTA recommend the GCTA-LDMS-I model, the authors of LD Score Regression...
9.
Holmes J, Speed D, Balding D
Genet Epidemiol
. 2019 Sep;
43(8):930-940.
PMID: 31541496
Linkage disequilibrium SCore regression (LDSC) has become a popular approach to estimate confounding bias, heritability, and genetic correlation using only genome-wide association study (GWAS) test statistics. SumHer is a newly...
10.
Speed D, Balding D
Nat Genet
. 2018 Dec;
51(2):277-284.
PMID: 30510236
We present SumHer, software for estimating confounding bias, SNP heritability, enrichments of heritability and genetic correlations using summary statistics from genome-wide association studies. The key difference between SumHer and the...