David Issadore
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Explore the profile of David Issadore including associated specialties, affiliations and a list of published articles.
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72
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1681
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Recent Articles
1.
Padilla M, Padilla M, Shepherd S, Hanna A, Kurnik M, Zhang X, et al.
bioRxiv
. 2025 Jan;
PMID: 39763759
Lipid nanoparticles (LNPs) are the most advanced delivery system currently available for RNA therapeutics. Their development has accelerated since the success of Patisiran, the first siRNA-LNP therapeutic, and the mRNA...
2.
Nong J, Gong X, Dang Q, Tiwari S, Patel M, Wu J, et al.
bioRxiv
. 2024 Nov;
PMID: 39605450
As they became the dominant gene therapy platform, lipid nanoparticles (LNPs) experienced nearly all their innovation in varying the structure of individual molecules in LNPs. This ignored control of the...
3.
Mossburg K, Shepherd S, Barragan D, O N, Berkow E, Maidment P, et al.
Eur J Nucl Med Mol Imaging
. 2024 Nov;
52(3):1177-1188.
PMID: 39528844
Purpose: Ultrasmall silver sulfide nanoparticles (AgS-NP) have been identified as promising contrast agents for a number of modalities and in particular for dual-energy mammography. These AgS-NP have demonstrated marked advantages...
4.
Kadam P, Yang Z, Lu Y, Zhu H, Atiyas Y, Shah N, et al.
BMC Biol
. 2024 Jul;
22(1):162.
PMID: 39075589
Background: Mitochondrial (mt) heteroplasmy can cause adverse biological consequences when deleterious mtDNA mutations accumulate disrupting "normal" mt-driven processes and cellular functions. To investigate the heteroplasmy of such mtDNA changes, we...
5.
Kadam P, Yang Z, Lu Y, Zhu H, Atiyas Y, Shah N, et al.
bioRxiv
. 2024 Jun;
PMID: 38915628
Background: Mitochondrial (mt) heteroplasmy can cause adverse biological consequences when deleterious mtDNA mutations accumulate disrupting 'normal' mt-driven processes and cellular functions. To investigate the heteroplasmy of such mtDNA changes we...
6.
Hanna A, Shepherd S, Issadore D, Mitchell M
Nanomedicine (Lond)
. 2024 Jan;
19(6):455-457.
PMID: 38240188
No abstract available.
7.
Mossburg K, Shepherd S, Barragan D, O N, Berkow E, Maidment P, et al.
bioRxiv
. 2023 Dec;
PMID: 38106126
Ultrasmall silver sulfide nanoparticles (Ag S-NP) have been identified as promising contrast agents for a number of modalities and in particular for dual-energy mammography. These Ag S-NP have demonstrated marked...
8.
Shen H, Zaitseva D, Yang Z, Forsythe L, Joergensen S, Zone A, et al.
Resuscitation
. 2023 Aug;
191:109937.
PMID: 37591443
Aim: Assessment of neurologic injury within the immediate hours following out-of-hospital cardiac arrest (OHCA) resuscitation remains a major clinical challenge. Extracellular vesicles (EVs), small bodies derived from cytosolic contents during...
9.
Lin A, Shen H, Spychalski G, Carpenter E, Issadore D
Sci Rep
. 2023 Aug;
13(1):13292.
PMID: 37587235
The isolation of specific subpopulations of extracellular vesicles (EVs) based on their expression of surface markers poses a significant challenge due to their nanoscale size (< 800 nm), their heterogeneous...
10.
Shepherd S, Han X, Mukalel A, El-Mayta R, Thatte A, Wu J, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(33):e2303567120.
PMID: 37556502
Lipid nanoparticles (LNPs) are a potent delivery technology that have made it possible for the recent clinical breakthroughs in mRNA therapeutics and vaccines. A key challenge to the broader implementation...