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David I Vernon

Explore the profile of David I Vernon including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 50
Followers 0
Related Specialties
Biology
Chemistry
General Surgery
Top 10 Co-Authors
Stanley B Brown
Ian Walker
Henricus J C M Sterenborg
Johanna T H M van den Akker
J Andrew Holroyd
John Griffiths
Russell D Cox
Andrea Bell
David J H Roberts
Clare L Conway
Published In
Photochem Photobiol Sci
Lasers Surg Med
Photochem Photobiol
Bioorg Med Chem Lett
Affiliations
Soon will be listed here.
Recent Articles
1.
In vivo and in vitro characterisation of a protoporphyrin IX-cyclic RGD peptide conjugate for use in photodynamic therapy
Conway C, Walker I, Bell A, Roberts D, Brown S, Vernon D
Photochem Photobiol Sci . 2008 Apr; 7(3):290-8. PMID: 18389145
Increasing treatment specificity is one of the major aims of cancer research. Photodynamic therapy is a clinically proven treatment for some cancers and certain other diseases. Photosensitisers generally have little...
2.
A comparative analysis of phenothiazinium salts for the photosensitisation of murine fibrosarcoma (RIF-1) cells in vitro
Walker I, Gorman S, Cox R, Vernon D, Griffiths J, Brown S
Photochem Photobiol Sci . 2004 Jul; 3(7):653-9. PMID: 15239000
Photodynamic therapy (PDT) is a treatment combining a photosensitiser, molecular oxygen and visible light of characteristic wavelength to produce cytotoxic reactive oxygen species (ROS). Within our centre, a series of...
3.
Chronic UVB exposure enhances in vitro percutaneous penetration of 5-aminulevulinic acid in hairless mouse skin
van den Akker J, Holroyd J, Vernon D, Sterenborg H, Brown S
Lasers Surg Med . 2004 Mar; 34(2):141-5. PMID: 15004826
Background And Objectives: (Pre)cancerous skin lesions accumulate more protoporphyrin IX (PpIX) upon topical application of 5-aminolevulinic acid (ALA) than the surrounding normal skin. This might be the result of a...
4.
Effect of elevating the skin temperature during topical ALA application on in vitro ALA penetration through mouse skin and in vivo PpIX production in human skin
van den Akker J, Boot K, Vernon D, Brown S, Groenendijk L, van Rhoon G, et al.
Photochem Photobiol Sci . 2004 Mar; 3(3):263-7. PMID: 14993942
An approach to induce increased protoporphyrin IX (PpIX) production in aminolevulinic acid (ALA)-based photodynamic therapy (PDT) of skin lesions is to elevate the skin temperature during topical ALA application. Increased...
5.
The solid-phase conjugation of purpurin-18 with a synthetic targeting peptide
Walker I, Vernon D, Brown S
Bioorg Med Chem Lett . 2003 Dec; 14(2):441-3. PMID: 14698177
It has been demonstrated that efficient site-specific coupling of the highly active photodynamic therapy sensitiser purpurin-18 to the synthetic targeting peptide G-G-V-K-R-K-K-K-P-G-Y-G can be achieved with greater than 85% purity.
6.
Comparative in vitro percutaneous penetration of 5-aminolevulinic acid and two of its esters through excised hairless mouse skin
van den Akker J, Holroyd J, Vernon D, Sterenborg H, Brown S
Lasers Surg Med . 2003 Sep; 33(3):173-81. PMID: 12949947
Background And Objectives: ALA esters have been developed to improve PpIX production in ALA-PDT, but they do not perform as well in skin as they do in cells and the...
7.
In vitro photodynamic activity of a series of methylene blue analogues
Mellish K, Cox R, Vernon D, Griffiths J, Brown S
Photochem Photobiol . 2002 May; 75(4):392-7. PMID: 12003129
We have synthesized a series of symmetrical phenothiazines in which the methyl groups of methylene blue have been substituted by longer alkyl chains. Intrinsic photosensitizing ability was not altered by...