David I Stuart
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Explore the profile of David I Stuart including associated specialties, affiliations and a list of published articles.
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299
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16865
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Recent Articles
11.
Liu C, Zhou D, Dijokaite-Guraliuc A, Supasa P, Duyvesteyn H, Ginn H, et al.
Cell Rep Med
. 2024 May;
5(5):101553.
PMID: 38723626
BA.2.86, a recently described sublineage of SARS-CoV-2 Omicron, contains many mutations in the spike gene. It appears to have originated from BA.2 and is distinct from the XBB variants responsible...
12.
Emerging variants develop total escape from potent monoclonal antibodies induced by BA.4/5 infection
Liu C, Das R, Dijokaite-Guraliuc A, Zhou D, Mentzer A, Supasa P, et al.
Nat Commun
. 2024 Apr;
15(1):3284.
PMID: 38627386
The rapid evolution of SARS-CoV-2 is driven in part by a need to evade the antibody response in the face of high levels of immunity. Here, we isolate spike (S)...
13.
Zhou D, Supasa P, Liu C, Dijokaite-Guraliuc A, Duyvesteyn H, Selvaraj M, et al.
Nat Commun
. 2024 Mar;
15(1):2734.
PMID: 38548763
Under pressure from neutralising antibodies induced by vaccination or infection the SARS-CoV-2 spike gene has become a hotspot for evolutionary change, leading to the failure of all mAbs developed for...
14.
Aitkenhead H, Riedel C, Cowieson N, Rumenapf H, Stuart D, El Omari K
Structure
. 2024 Jan;
32(3):273-281.e4.
PMID: 38176409
Pestiviruses, within the family Flaviviridae, are economically important viruses of livestock. In recent years, new pestiviruses have been reported in domestic animals and non-cloven-hoofed animals. Among them, atypical porcine pestivirus...
15.
Bou-Antoun S, Rokadiya S, Ashiru-Oredope D, Demirjian A, Sherwood E, Ellaby N, et al.
J Antimicrob Chemother
. 2023 Nov;
78(Suppl 2):ii37-ii42.
PMID: 37995354
The COVID-19 pandemic saw unprecedented resources and funds driven into research for the development, and subsequent rapid distribution, of vaccines, diagnostics and directly acting antivirals (DAAs). DAAs have undeniably prevented...
16.
Ni T, Mendonca L, Zhu Y, Howe A, Radecke J, Shah P, et al.
iScience
. 2023 Sep;
26(10):107882.
PMID: 37766989
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been proven to be an effective means of decreasing COVID-19 mortality, hospitalization rates, and transmission. One of the vaccines deployed...
17.
Aitkenhead H, Stuart D, El Omari K
Viruses
. 2023 Jul;
15(7).
PMID: 37515111
CD46, or membrane cofactor protein, is a type-one transmembrane protein from the complement regulatory protein family. Alongside its role in complement activation, CD46 is involved in many other processes, from...
18.
Chenthamarakshan V, Hoffman S, Owen C, Lukacik P, Strain-Damerell C, Fearon D, et al.
Sci Adv
. 2023 Jun;
9(25):eadg7865.
PMID: 37343087
Inhibitor discovery for emerging drug-target proteins is challenging, especially when target structure or active molecules are unknown. Here, we experimentally validate the broad utility of a deep generative framework trained...
19.
Ragonnet-Cronin M, Nutalai R, Huo J, Dijokaite-Guraliuc A, Das R, Tuekprakhon A, et al.
Nat Commun
. 2023 Jun;
14(1):3334.
PMID: 37286554
COVID-19 patients at risk of severe disease may be treated with neutralising monoclonal antibodies (mAbs). To minimise virus escape from neutralisation these are administered as combinations e.g. casirivimab+imdevimab or, for...
20.
Zhou D, Ren J, Fry E, Stuart D
Curr Opin Virol
. 2023 Jun;
61:101332.
PMID: 37285620
The COVID-19 pandemic caused by SARS-CoV-2 has led to hundreds of millions of infections and millions of deaths, however, human monoclonal antibodies (mAbs) can be an effective treatment. Since SARS-CoV-2...