David H Spencer
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Explore the profile of David H Spencer including associated specialties, affiliations and a list of published articles.
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55
Citations
5349
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Recent Articles
1.
Valentine M, Wong A, Chen L, Du F, Hughes A, Spencer D, et al.
Int J Gynecol Cancer
. 2025 Feb;
35(2):100060.
PMID: 39971443
Objective: The molecular classification of endometrial cancer into POLE-ultra-mutated, mismatch repair-deficient, p53-mutated, and no specific molecular profile sub-types has significant prognostic value and is recommended in the evaluation of all...
2.
Jadlowsky J, Chang J, Spencer D, Warrington J, Levine B, June C, et al.
Cancer Immunol Res
. 2024 Jul;
12(9):1132-1135.
PMID: 39018097
Methods to engineer the genomes of human cells for therapeutic intervention continue to advance at a remarkable pace. Chimeric antigen receptor-engineered T lymphocytes have pioneered the way for these therapies,...
3.
Arthur N, Christensen K, Mannino K, Ruzinova M, Kumar A, Gruszczynska A, et al.
Clin Cancer Res
. 2024 Jun;
30(16):3622-3639.
PMID: 38848040
Purpose: Somatic missense mutations in the phosphodegron domain of the MYC gene (MYC Box I or MBI) are detected in the dominant clones of a subset of patients with acute...
4.
Gruszczynska A, Maiti A, Miller C, Ramakrishnan S, Link D, Uy G, et al.
Haematologica
. 2024 Apr;
109(8):2653-2659.
PMID: 38618679
No abstract available.
5.
Mojarad B, Crees Z, Schroeder M, Xiang Z, Vader J, Sina J, et al.
Cancer Genet
. 2023 Dec;
280-281:1-5.
PMID: 38056049
Background: Only rare cases of acute myeloid leukemia (AML) have been shown to harbor a t(8;11)(p11.2;p15.4). This translocation is believed to involve the fusion of NSD3 or FGFR1 with NUP98;...
6.
Arthur N, Christensen K, Mannino K, Ruzinova M, Kumar A, Gruszczynska A, et al.
bioRxiv
. 2023 Nov;
PMID: 37961226
Somatic missense mutations in the phosphodegron domain of the gene ( M YC Box I) are detected in the dominant clones of a subset of acute myeloid leukemia (AML) patients,...
7.
Abel H, Oetjen K, Miller C, Ramakrishnan S, Day R, Helton N, et al.
Blood Adv
. 2023 Jun;
7(16):4586-4598.
PMID: 37339484
TP53-mutated myeloid malignancies are associated with complex cytogenetics and extensive structural variants, which complicates detailed genomic analysis by conventional clinical techniques. We performed whole-genome sequencing (WGS) of 42 acute myeloid...
8.
Slade M, Ghasemi R, OLaughlin M, Burton T, Fulton R, Abel H, et al.
JCO Precis Oncol
. 2023 Apr;
7:e2200559.
PMID: 37079859
Purpose: Persistent molecular disease (PMD) after induction chemotherapy predicts relapse in AML. In this study, we used whole-exome sequencing (WES) and targeted error-corrected sequencing to assess the frequency and mutational...
9.
Issa N, Bjeije H, Wilson E, Krishnan A, Dunuwille W, Parsons T, et al.
Leukemia
. 2023 Feb;
37(4):728-740.
PMID: 36797416
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic neoplasm resulting from the malignant transformation of T-cell progenitors. While activating NOTCH1 mutations are the dominant genetic drivers of T-ALL, epigenetic...
10.
Abel H, Oetjen K, Miller C, Ramakrishnan S, Day R, Helton N, et al.
medRxiv
. 2023 Jan;
PMID: 36711871
Key Points: WGS comprehensively determines mutation status, resulting in the reclassification of 12% of cases from mono-allelic to multi-hit Chromothripsis is more frequent than previously appreciated, with a preference for...