David H Overstreet
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Explore the profile of David H Overstreet including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Overstreet D, Wegener G
Pharmacol Rev
. 2013 Jan;
65(1):143-55.
PMID: 23319547
Approximately 25 years have passed since the first publication suggesting the Flinders sensitive line (FSL) rat as an animal model of depression. At least 6 years of research on these...
2.
Rezvani A, Lawrence A, Arolfo M, Levin E, Overstreet D
Recent Pat CNS Drug Discov
. 2012 May;
7(2):151-62.
PMID: 22574676
Alcoholism is a complex heterogeneous disease and a number of neurotransmitter and neuromodulator systems have been implicated in its manifestation. Consequently, it is unlikely that existing medications such as disulfiram...
3.
Overstreet D
Methods Mol Biol
. 2012 Jan;
829:125-44.
PMID: 22231810
Animal models and preclinical tests have played large roles in the development of antidepressant drugs and are likely to continue to play important roles. In the present communication, the main...
4.
Knapp D, Overstreet D, Huang M, Wills T, Whitman B, Angel R, et al.
Psychopharmacology (Berl)
. 2011 Jun;
218(1):179-89.
PMID: 21643675
Rationale: Stress may elevate ethanol drinking and anxiety associated with ethanol drinking. Studies to identify relevant neurobiological substrates are needed. Objective: To assess roles of brain regions in corticotrophin releasing...
5.
Knapp D, Whitman B, Wills T, Angel R, Overstreet D, Criswell H, et al.
Brain Behav Immun
. 2011 Mar;
25 Suppl 1:S146-54.
PMID: 21377524
Stress has been shown to facilitate ethanol withdrawal-induced anxiety. Defining neurobiological mechanisms through which stress has such actions is important given the associated risk of relapse. While CRF has long...
6.
Huang W, Heffernan M, Li Z, Zhang N, Overstreet D, King J
Neurosci Lett
. 2010 Dec;
489(2):74-8.
PMID: 21134416
Previous human imaging studies used facial stimuli to explore the potential association between depression and fear. This study aimed at investigating brain alterations in a rodent model of depression when...
7.
Kotsovolou O, Ingelman-Sundberg M, Lang M, Marselos M, Overstreet D, Papadopoulou-Daifoti Z, et al.
Prog Neuropsychopharmacol Biol Psychiatry
. 2010 Jul;
34(6):1075-84.
PMID: 20595028
The Flinders Sensitive Line (FSL) rat model of depression exhibits some behavioral, neurochemical, and pharmacological features that have been reported in depressed patients and has been very effective in screening...
8.
Wills T, Knapp D, Overstreet D, Breese G
Alcohol Clin Exp Res
. 2010 Jul;
34(9):1603-12.
PMID: 20586753
Background: Repeated stress or administration of corticotropin-releasing factor (CRF) prior to ethanol exposure sensitizes anxiety-like behavior in adult rats. Current experiments determined whether adolescent rats were more sensitive to these...
9.
Overstreet D, Naimoli V, Griebel G
Pharmacol Biochem Behav
. 2010 May;
96(2):206-10.
PMID: 20470817
Previous work established that saredutant, an NK2 receptor antagonist, has antidepressant and anxiolytic-antistress effects in a variety of rodent models. The purpose of the present investigation was two-fold: to confirm...
10.
Glantz L, Gilmore J, Overstreet D, Salimi K, Lieberman J, Jarskog L
Schizophr Res
. 2010 Jan;
118(1-3):292-9.
PMID: 20067857
Although the etiology of schizophrenia remains unknown, diverse neuropathological evidence suggests a disorder of synaptic connectivity. Apoptosis is a form of cell death that helps determine synaptic circuitry during neurodevelopment...