David Gresham
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Explore the profile of David Gresham including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Spealman P, de Santana C, De T, Gresham D
bioRxiv
. 2023 Nov;
PMID: 37961325
Copy-number variants (CNVs) are an important class of recurrent variants that mediate adaptive evolution. While CNVs can increase the relative fitness of the organism, they can also incur a cost....
12.
Jackson C, Beheler-Amass M, Tjarnberg A, Suresh I, Hickey A, Bonneau R, et al.
bioRxiv
. 2023 Oct;
PMID: 37790443
Cells respond to environmental and developmental stimuli by remodeling their transcriptomes through regulation of both mRNA transcription and mRNA decay. A central goal of biology is identifying the global set...
13.
Avecilla G, Spealman P, Matthews J, Caudal E, Schacherer J, Gresham D
Genome Res
. 2023 Aug;
33(8):1340-1353.
PMID: 37652668
Copy number variants (CNVs), duplications and deletions of genomic sequences, contribute to evolutionary adaptation but can also confer deleterious effects and cause disease. Whereas the effects of amplifying individual genes...
14.
Sun S, Tranchina D, Gresham D
bioRxiv
. 2023 Aug;
PMID: 37577636
Cells arrest growth and enter a quiescent state upon nutrient deprivation. However, the molecular processes by which cells respond to different starvation signals to regulate exit from the cell division...
15.
Knoll M, Honce R, Meliopoulos V, Schultz-Cherry S, Ghedin E, Gresham D
bioRxiv
. 2023 Jul;
PMID: 37503024
Obesity is a chronic health condition characterized by excess adiposity leading to a systemic increase in inflammation and dysregulation of metabolic hormones and immune cell populations. Obesity is well established...
16.
Xie Y, Liu T, Gresham D, Holt L
bioRxiv
. 2023 Jul;
PMID: 37398029
The intracellular environment is packed with macromolecules of mesoscale size, and this crowded milieu significantly influences cell physiology. When exposed to stress, mRNAs released after translational arrest condense with RNA...
17.
Spealman P, De T, Chuong J, Gresham D
J Mol Evol
. 2023 Apr;
91(3):356-368.
PMID: 37012421
Copy number variants (CNVs), comprising gene amplifications and deletions, are a pervasive class of heritable variation. CNVs play a key role in rapid adaptation in both natural, and experimental, evolution....
18.
Xie Y, Gresham D, Holt L
MicroPubl Biol
. 2023 Mar;
2023.
PMID: 36908311
Macromolecular crowding is an important property of cells that impacts multiple biological processes. Passive microrheology using single particle tracking is a powerful means of studying macromolecular crowding. Here we monitored...
19.
Taylor K, Agu I, Jose I, Mantynen S, Campbell A, Mattson C, et al.
PLoS Pathog
. 2023 Mar;
19(3):e1011155.
PMID: 36857394
RNA viruses can exchange genetic material during coinfection, an interaction that creates novel strains with implications for viral evolution and public health. Influenza A viral genetic exchange can occur when...
20.
de Santana C, Spealman P, Gresham D, Perron G
Microbiol Resour Announc
. 2023 Feb;
12(3):e0101522.
PMID: 36779724
Many modern farming practices negatively impact ecosystems on the local and global scales. Here, we assessed the taxonomic structures of 48 soil microbial communities along an agricultural transect using 16S...