David Gonzalez-Forero
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Explore the profile of David Gonzalez-Forero including associated specialties, affiliations and a list of published articles.
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23
Citations
459
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Recent Articles
1.
Garcia-Morales V, Gento-Caro A, Portillo F, Montero F, Gonzalez-Forero D, Moreno-Lopez B
Front Mol Neurosci
. 2021 Dec;
14:788039.
PMID: 34938160
Intrinsic membrane excitability (IME) sets up neuronal responsiveness to synaptic drive. Several neurotransmitters and neuromodulators, acting through G-protein-coupled receptors (GPCRs), fine-tune motoneuron (MN) IME by modulating background K channels TASK1....
2.
Gento-Caro A, Vilches-Herrando E, Portillo F, Gonzalez-Forero D, Moreno-Lopez B
Brain Pathol
. 2021 Sep;
32(3):e13022.
PMID: 34585475
A preclinical strategy to broaden the search of potentially effective treatments in amyotrophic lateral sclerosis (ALS) relies on identifying factors controlling motor neuron (MN) excitability. These partners might be part...
3.
Gento-Caro A, Vilches-Herrando E, Garcia-Morales V, Portillo F, Rodriguez-Bey G, Gonzalez-Forero D, et al.
Neuropathol Appl Neurobiol
. 2021 Jan;
47(7):1004-1018.
PMID: 33508894
Aims: Alterations in excitability represent an early hallmark in Amyotrophic Lateral Sclerosis (ALS). Therefore, deciphering the factors that impact motor neuron (MN) excitability offers an opportunity to uncover further aetiopathogenic...
4.
Garcia-Morales V, Rodriguez-Bey G, Gomez-Perez L, Dominguez-Vias G, Gonzalez-Forero D, Portillo F, et al.
Nat Commun
. 2019 Aug;
10(1):3784.
PMID: 31439839
Disruption in membrane excitability contributes to malfunction and differential vulnerability of specific neuronal subpopulations in a number of neurological diseases. The adaptor protein p11, and background potassium channel TASK1, have...
5.
Garcia-Morales V, Montero F, Gonzalez-Forero D, Rodriguez-Bey G, Gomez-Perez L, Medialdea-Wandossell M, et al.
PLoS Biol
. 2015 May;
13(5):e1002153.
PMID: 25996636
Synaptic communication is a dynamic process that is key to the regulation of neuronal excitability and information processing in the brain. To date, however, the molecular signals controlling synaptic dynamics...
6.
Gonzalez-Forero D, Montero F, Garcia-Morales V, Dominguez G, Gomez-Perez L, Garcia-Verdugo J, et al.
J Neurosci
. 2012 Jan;
32(1):68-84.
PMID: 22219271
Rho-associated kinase (ROCK) regulates neural cell migration, proliferation and survival, dendritic spine morphology, and axon guidance and regeneration. There is, however, little information about whether ROCK modulates the electrical activity...
7.
Fontan-Lozano A, Suarez-Pereira I, Gonzalez-Forero D, Carrion A
PLoS One
. 2011 Oct;
6(9):e24915.
PMID: 21966384
Synaptic plasticity involves short- and long-term events, although the molecular mechanisms that underlie these processes are not fully understood. The transient A-type K(+) current (I(A)) controls the excitability of the...
8.
Moreno-Lopez B, Sunico C, Gonzalez-Forero D
Mol Neurobiol
. 2010 Dec;
43(1):41-66.
PMID: 21190141
Synapse elimination is the main factor responsible for the cognitive decline accompanying many of the neuropathological conditions affecting humans. Synaptic stripping of motoneurons is also a common hallmark of several...
9.
Sunico C, Gonzalez-Forero D, Dominguez G, Garcia-Verdugo J, Moreno-Lopez B
J Neurosci
. 2010 Jan;
30(3):973-84.
PMID: 20089906
The molecular signaling that underpins synapse loss in neuropathological conditions remains unknown. Concomitant upregulation of the neuronal nitric oxide (NO) synthase (nNOS) in neurodegenerative processes places NO at the center...
10.
Montero F, Portillo F, Gonzalez-Forero D, Moreno-Lopez B
Eur J Neurosci
. 2008 Jul;
28(1):107-16.
PMID: 18616563
Motoneurons integrate interneuronal activity into commands for skeletal muscle contraction and relaxation to perform motor actions. Hypoglossal motoneurons (HMNs) are involved in essential motor functions such as breathing, mastication, swallowing...