David Givol
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Explore the profile of David Givol including associated specialties, affiliations and a list of published articles.
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36
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1641
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Recent Articles
11.
Nardinocchi L, Puca R, Givol D, DOrazi G
FEBS Lett
. 2010 Sep;
584(19):4253-8.
PMID: 20849851
Homeodomain-interacting protein kinase-2 (HIPK2) is a crucial regulator of p53 apoptotic function by phosphorylating serine 46 (Ser46) in response to DNA damage. In tumors with wild-type p53, its tumor suppressor...
12.
Nardinocchi L, Puca R, Givol D, DOrazi G
Cell Cycle
. 2010 Mar;
9(7):1270-5.
PMID: 20234185
Oncosuppressor p53 is often inactivated by either mutations or deregulation of regulatory proteins. These include the homeodomain-interacting protein kinase 2 (HIPK2) that, by phosphorylating p53 at Ser46 modulates p53 response...
13.
Yakubov E, Rechavi G, Rozenblatt S, Givol D
Biochem Biophys Res Commun
. 2010 Mar;
394(1):189-93.
PMID: 20188704
Reprogramming of differentiated cells into induced pluripotent cells (iPS) was accomplished in 2006 by expressing four, or less, embryonic stem cell (ESC)-specific transcription factors. Due to the possible danger of...
14.
Puca R, Nardinocchi L, Starace G, Rechavi G, Sacchi A, Givol D, et al.
Free Radic Biol Med
. 2010 Feb;
48(10):1338-46.
PMID: 20171273
HIPK2 is a stress-induced kinase and a transcriptional corepressor that functionally cooperates with p53 to suppress cancer. Activation of the p53 proapoptotic function requires a cascade of phosphorylations and acetylations,...
15.
Puca R, Nardinocchi L, Sacchi A, Rechavi G, Givol D, DOrazi G
Mol Cancer
. 2009 Oct;
8:85.
PMID: 19828042
Background: Activation of p53-mediated gene transcription is a critical cellular response to DNA damage and involves a phosphorylation-acetylation cascade of p53. The discovery of differences in the response to different...
16.
Nardinocchi L, Puca R, Sacchi A, Rechavi G, Givol D, DOrazi G
PLoS One
. 2009 Aug;
4(8):e6819.
PMID: 19714248
Background: The tumor suppressor homeodomain-interacting protein kinase-2 (HIPK2) by phosphorylating serine 46 (Ser46) is a crucial regulator of p53 apoptotic function. HIPK2 is also a transcriptional co-repressor of hypoxia-inducible factor-1alpha...
17.
Lapi E, Di Agostino S, Donzelli S, Gal H, Domany E, Rechavi G, et al.
Mol Cell
. 2008 Dec;
32(6):803-14.
PMID: 19111660
p73 has been identified as a structural and functional homolog of the tumor suppressor p53. The transcriptional coactivator Yes-associated protein (YAP) has been demonstrated to interact with and to enhance...
18.
Puca R, Nardinocchi L, Bossi G, Sacchi A, Rechavi G, Givol D, et al.
Exp Cell Res
. 2008 Nov;
315(1):67-75.
PMID: 18996371
The maintenance of p53 transactivation activity is important for p53 apoptotic function. We have shown that stable knockdown of HIPK2 induces p53 misfolding with inhibition of p53 target gene transcription....
19.
Matsushita T, Wilcox W, Chan Y, Kawanami A, Bukulmez H, Balmes G, et al.
Hum Mol Genet
. 2008 Oct;
18(2):227-40.
PMID: 18923003
Activating mutations in FGFR3 cause achondroplasia and thanatophoric dysplasia, the most common human skeletal dysplasias. In these disorders, spinal canal and foramen magnum stenosis can cause serious neurologic complications. Here,...
20.
Gal H, Pandi G, Kanner A, Ram Z, Lithwick-Yanai G, Amariglio N, et al.
Biochem Biophys Res Commun
. 2008 Sep;
376(1):86-90.
PMID: 18765229
We examined the microRNA profiles of Glioblastoma stem (CD133+) and non-stem (CD133-) cell populations and found up-regulation of several miRs in the CD133- cells, including miR-451, miR-486, and miR-425, some...