David F Gebhard
Overview
Explore the profile of David F Gebhard including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
243
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0
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Recent Articles
1.
Hoffman A, Nolan J, Gebhard D, Nickischer D, Omta W, Cooper S, et al.
Assay Drug Dev Technol
. 2018 Jan;
16(1):1-6.
PMID: 29345980
No abstract available.
2.
Michaud N, Jani J, Hillerman S, Tsaparikos K, Barbacci-Tobin E, Knauth E, et al.
MAbs
. 2012 Sep;
4(6):710-23.
PMID: 23007574
The c-Met proto-oncogene is a multifunctional receptor tyrosine kinase that is stimulated by its ligand, hepatocyte growth factor (HGF), to induce cell growth, motility and morphogenesis. Dysregulation of c-Met function,...
3.
Bagi C, Gebhard D, Andresen C
Eur J Gastroenterol Hepatol
. 2012 Feb;
24(5):563-74.
PMID: 22314934
Objective: Tumor recurrence and metastasis is the most common cause of mortality in hepatocellular carcinoma (HCC) patients. Despite positive results with vascular endothelial growth factor (VEGF) inhibitors in preclinical studies...
4.
Di L, Whitney-Pickett C, Umland J, Zhang H, Zhang X, Gebhard D, et al.
J Pharm Sci
. 2011 Jul;
100(11):4974-85.
PMID: 21766308
Permeability is an important property of drug candidates. The Madin-Darby canine kidney cell line (MDCK) permeability assay is widely used and the primary concern of using MDCK cells is the...
5.
Nadanaciva S, Murray J, Wilson C, Gebhard D, Will Y
Curr Protoc Toxicol
. 2011 May;
Chapter 3:Unit3.11.
PMID: 21553395
Compounds that impair the synthesis of either mitochondrial DNA (mtNDA) or mtDNA-encoded proteins reduce the levels of 13 proteins essential for oxidative phosphorylation, leading to a decrease in mitochondrial ATP...
6.
Nadanaciva S, Lu S, Gebhard D, Jessen B, Pennie W, Will Y
Toxicol In Vitro
. 2010 Dec;
25(3):715-23.
PMID: 21184822
Lysosomes are acidic organelles that are essential for the degradation of old organelles and engulfed microbes. Furthermore, lysosomes play a key role in cell death. Lipophilic or amphiphilic compounds with...
7.
Nadanaciva S, Dillman K, Gebhard D, Shrikhande A, Will Y
J Biomol Screen
. 2010 Jul;
15(8):937-48.
PMID: 20625181
Compounds that interfere with the synthesis of either mitochondrial DNA or mtDNA-encoded proteins reduce the levels of 13 proteins essential for oxidative phosphorylation, leading to a decrease in mitochondrial adenosine...
8.
Buckbinder L, Crawford D, Qi H, Ke H, Olson L, Long K, et al.
Proc Natl Acad Sci U S A
. 2007 Jun;
104(25):10619-24.
PMID: 17537919
Bone is accrued and maintained primarily through the coupled actions of bone-forming osteoblasts and bone-resorbing osteoclasts. Cumulative in vitro studies indicated that proline-rich tyrosine kinase 2 (PYK2) is a positive...