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David E Whitworth

Explore the profile of David E Whitworth including associated specialties, affiliations and a list of published articles. Areas
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Articles 66
Citations 1070
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Recent Articles
11.
Khalid A, Cookson A, Whitworth D, Beeton M, Robins L, Maddocks S
Pathogens . 2023 Jan; 12(1). PMID: 36678466
Understanding chronic wound infection is key for successful treatment and requires accurate laboratory models. We describe a modified biofilm flow device that effectively mimics the chronic wound environment, including simulated...
12.
Arakal B, Whitworth D, James P, Rowlands R, Madhusoodanan N, Baijoo M, et al.
Probiotics Antimicrob Proteins . 2022 Dec; 15(1):202-214. PMID: 36586039
Antimicrobial resistance (AMR) is a global concern, and as soon as new antibiotics are introduced, resistance to those agents emerges. Therefore, there is an increased appetite for alternative antimicrobial agents...
13.
Ghosh D, Whitworth D, Schafer H, Krishnamurthi S, Saha P
Front Microbiol . 2022 Oct; 13:1015111. PMID: 36312932
No abstract available.
14.
Whitworth D
Microorganisms . 2022 Apr; 10(4). PMID: 35456855
Myxobacteria are fascinating and important prokaryotes [...].
15.
Whitworth D, Sydney N, Radford E
Microorganisms . 2021 Oct; 9(10). PMID: 34683464
Myxobacteria are fascinating and complex microbes. They prey upon other members of the soil microbiome by secreting antimicrobial proteins and metabolites, and will undergo multicellular development if starved. The genome...
16.
Ortet P, Fochesato S, Bitbol A, Whitworth D, Lalaouna D, Santaella C, et al.
Sci Rep . 2021 Jun; 11(1):11763. PMID: 34083699
Two-component systems (TCSs) are ubiquitous signaling pathways, typically comprising a sensory histidine kinase (HK) and a response regulator, which communicate via intermolecular kinase-to-receiver domain phosphotransfer. Hybrid HKs constitute non-canonical TCS...
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Sydney N, Swain M, So J, Hoiczyk E, Tucker N, Whitworth D
Microb Physiol . 2021 Apr; 31(2):57-66. PMID: 33794538
Bacterial predation is a ubiquitous and fundamental biological process, which influences the community composition of microbial ecosystems. Among the best characterised bacterial predators are the myxobacteria, which include the model...
19.
Whitworth D, Zwarycz A
Microorganisms . 2020 Nov; 8(11). PMID: 33171896
As prokaryotes diverge by evolution, essential 'core' genes required for conserved phenotypes are preferentially retained, while inessential 'accessory' genes are lost or diversify. We used the recently expanded number of...
20.
Chambers J, Sparks N, Sydney N, Livingstone P, Cookson A, Whitworth D
Genome Biol Evol . 2020 Oct; 12(12):2289-2302. PMID: 33022031
Members of the predatory Myxococcales (myxobacteria) possess large genomes, undergo multicellular development, and produce diverse secondary metabolites, which are being actively prospected for novel drug discovery. To direct such efforts,...