David E Moorman
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Explore the profile of David E Moorman including associated specialties, affiliations and a list of published articles.
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41
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1828
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Recent Articles
1.
Nippert K, Rowland C, Vazey E, Moorman D
Neuropharmacology
. 2024 Aug;
260:110114.
PMID: 39134298
Cognitive flexibility enables individuals to alter their behavior in response to changing environmental demands, facilitating optimal behavior in a dynamic world. The inability to do this, called behavioral inflexibility, is...
2.
Moorman D, Aston-Jones G
Psychopharmacology (Berl)
. 2022 Dec;
240(3):575-594.
PMID: 36464693
Rationale And Objectives: The prefrontal cortex is critical for execution and inhibition of reward seeking. Neural manipulation of rodent medial prefrontal cortex (mPFC) subregions differentially impacts execution and inhibition of...
3.
Kaminska B, Caballero J, Moorman D
Int Rev Neurobiol
. 2021 Mar;
158:57-82.
PMID: 33785156
The rodent medial prefrontal cortex (mPFC) plays a key role in regulating cognition, emotion, and behavior. mPFC neurons are activated in diverse experimental paradigms, raising the questions of whether there...
4.
Hernandez J, Moorman D
eNeuro
. 2020 Jul;
7(4).
PMID: 32661066
Orbitofrontal cortex (OFC) plays a key role in representation and regulation of reward value, preference, and seeking. OFC function is disrupted in drug use and dependence, but its specific role...
5.
Hernandez J, Binette A, Rahman T, Tarantino J, Moorman D
Alcohol Clin Exp Res
. 2020 Jul;
44(9):1769-1782.
PMID: 32628778
Background: The orbitofrontal cortex (OFC) encodes internal representations of outcomes and subjective value to facilitate flexible reward seeking. OFC activation is associated with drug seeking in both human subjects and...
6.
den Hartog C, Blandino K, Nash M, Sjogren E, Grampetro M, Moorman D, et al.
Psychopharmacology (Berl)
. 2020 Jun;
237(10):3021-3031.
PMID: 32588079
Rationale: Stress plays a major role in the development of alcohol use disorder (AUD)-a history of chronic stress contributes to alcohol misuse, and withdrawal from alcohol elevates stress, perpetuating cycles...
7.
Arinze I, Moorman D
Neuropharmacology
. 2020 Feb;
168:108007.
PMID: 32092436
The orbitofrontal cortex (OFC) plays a fundamental role in motivated behavior and decision-making. In humans, OFC structure and function is significantly disrupted in drug using and dependent individuals, including those...
8.
Caballero J, Scarpa G, Remage-Healey L, Moorman D
eNeuro
. 2019 Sep;
6(5).
PMID: 31519696
Rodent dorsal medial prefrontal cortex (mPFC), typically prelimbic cortex, is often described as promoting actions such as reward seeking, whereas ventral mPFC, typically infralimbic cortex, is thought to promote response...
9.
Bercovici D, Princz-Lebel O, Tse M, Moorman D, Floresco S
eNeuro
. 2019 Jan;
5(6).
PMID: 30627636
Decision making often requires weighing costs and benefits of different options that vary in terms of reward magnitude and uncertainty. Previous studies using pharmacological inactivations have shown that the basolateral...
10.
Vazey E, Moorman D, Aston-Jones G
Proc Natl Acad Sci U S A
. 2018 Sep;
115(40):E9439-E9448.
PMID: 30232259
Phasic activation of locus coeruleus (LC)-norepinephrine (NE) neurons is associated with focused attention and behavioral responses to salient stimuli. We used cell-type-specific optogenetics and single-unit neurophysiology to identify how LC...