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» Authors » David E Lefebvre

David E Lefebvre

Explore the profile of David E Lefebvre including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 17
Citations 289
Followers 0
Related Specialties
Toxicology
Endocrinology
Biotechnology
Top 10 Co-Authors
Genevieve S Bondy
Fraser W Scott
Laurie Coady
Ivan Curran
Nikia Ross
Rekha Mehta
Virginia Liston
Azam F Tayabali
Jason H Fine
Don Caldwell
Published In
Diabetes
Nanotoxicology
J Immunol Methods
J Toxicol Environ Health A
Toxicol Sci
Affiliations
Soon will be listed here.
Recent Articles
11.
Promotion of autoimmune diabetes by cereal diet in the presence or absence of microbes associated with gut immune activation, regulatory imbalance, and altered cathelicidin antimicrobial Peptide
Patrick C, Wang G, Lefebvre D, Crookshank J, Sonier B, Eberhard C, et al.
Diabetes . 2013 Jan; 62(6):2036-47. PMID: 23349499
We are exposed to millions of microbial and dietary antigens via the gastrointestinal tract, which likely play a key role in type 1 diabetes (T1D). We differentiated the effects of...
12.
Toxicologic and immunologic effects of perinatal exposure to the brominated diphenyl ether (BDE) mixture DE-71 in the Sprague-Dawley rat
Bondy G, Lefebvre D, Aziz S, Cherry W, Coady L, MacLellan E, et al.
Environ Toxicol . 2011 May; 28(4):215-28. PMID: 21544923
Brominated diphenyl ethers (BDEs) are persistent environmental contaminants found in human blood, tissues, and milk. To assess the impact of the commercial BDE mixture DE-71 on the developing immune system...
13.
Diabetes-specific HLA-DR-restricted proinflammatory T-cell response to wheat polypeptides in tissue transglutaminase antibody-negative patients with type 1 diabetes
Mojibian M, Chakir H, Lefebvre D, Crookshank J, Sonier B, Keely E, et al.
Diabetes . 2009 Apr; 58(8):1789-96. PMID: 19401421
Objective: There is evidence of gut barrier and immune system dysfunction in some patients with type 1 diabetes, possibly linked with exposure to dietary wheat polypeptides (WP). However, questions arise...
14.
Immunomodulatory effects of dietary potassium perfluorooctane sulfonate (PFOS) exposure in adult Sprague-Dawley rats
Lefebvre D, Curran I, Armstrong C, Coady L, Parenteau M, Liston V, et al.
J Toxicol Environ Health A . 2008 Oct; 71(23):1516-25. PMID: 18923994
Perfluorooctanesulfonate (PFOS) is a stable and environmentally persistent metabolic or degradation product of perfluorooctanyl compounds that were manufactured for a variety of industrial and consumer applications. PFOS itself was sold...
15.
Dietary proteins as environmental modifiers of type 1 diabetes mellitus
Lefebvre D, Powell K, Strom A, Scott F
Annu Rev Nutr . 2006 Jul; 26:175-202. PMID: 16848704
Type 1 diabetes is an autoimmune disease in which the patient's immune system destroys the insulin-secreting beta-cells in the pancreatic islets of Langerhans. A majority of cases is thought to...
16.
Immune reactivity to a glb1 homologue in a highly wheat-sensitive patient with type 1 diabetes and celiac disease
Mojibian M, Chakir H, MacFarlane A, Lefebvre D, Webb J, Touchie C, et al.
Diabetes Care . 2006 Apr; 29(5):1108-10. PMID: 16644646
No abstract available.
17.
T-bet/GATA-3 ratio as a measure of the Th1/Th2 cytokine profile in mixed cell populations: predominant role of GATA-3
Chakir H, Wang H, Lefebvre D, Webb J, Scott F
J Immunol Methods . 2003 Sep; 278(1-2):157-69. PMID: 12957404
The differentiation of naive T-helper (Th) cells towards Th1 or Th2 cells is regulated by the transcription factors T-box expressed in T-cells (T-bet) and GATA-binding protein-3 (GATA-3). In the present...