David E Clemmer
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Explore the profile of David E Clemmer including associated specialties, affiliations and a list of published articles.
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206
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3581
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Recent Articles
1.
Biricioiu M, Sarbu M, Ica R, Vukelic Z, Clemmer D, Zamfir A
Biochimie
. 2025 Jan;
PMID: 39884374
Anencephaly, the most severe type of neural tube defects (NTDs) in humans, occurs between the third and fourth gestational weeks (GW), involves the cranial part of the NT and results...
2.
Sharif D, Dewasurendra V, Sultana M, Mahmud S, Banerjee C, Rahman M, et al.
J Phys Chem B
. 2025 Jan;
129(5):1626-1639.
PMID: 39878076
Capillary vibrating sharp-edge spray ionization (cVSSI) has been used to control the droplet charging of nebulized microdroplets and monitor effects on protein ion conformation makeup as determined by mass spectrometry...
3.
Ma Y, Zhao B, Gautam A, Davis C, Trinidad J, Reilly J, et al.
J Am Soc Mass Spectrom
. 2025 Jan;
36(2):277-285.
PMID: 39843390
The effectiveness of state-of-the-art cross-linking strategies and mass spectrometry (MS) detection was explored in an important biological context, namely, the ubiquitin-proteasome system, which is responsible for most of the regulated...
4.
Pan H, Klein S, Gunaratne A, Jarrold M, Clemmer D
Anal Chem
. 2025 Jan;
97(2):1419-1425.
PMID: 39772511
Charge detection mass spectrometry (CD-MS) is used to monitor the dissociation of large (300 kDa to 20 MDa) protein complexes in droplets heated with a 10.6 μm CO laser. In...
5.
Sharma A, Srivastava R, Gnyawali S, Bhasme P, Anthony A, Xuan Y, et al.
ACS Nano
. 2024 Oct;
18(44):30405-30420.
PMID: 39453865
Tissue nanotransfection (TNT)-based fluorescent labeling of cell-specific exosomes has shown that exosomes play a central role in physiological keratinocyte-macrophage (mϕ) crosstalk at the wound-site. Here, we report that during the...
6.
Sharon E, OKeefe S, Grassmyer K, Raab S, Maloney T, Clemmer D
Anal Chem
. 2024 Sep;
PMID: 39250816
Synthetic oligonucleotides have emerged as effective therapeutics that regulate gene expression to treat and prevent diseases. Oligonucleotide therapeutics are often modified with a substitution of a phosphorothioate (PS) linkage along...
7.
Sarbu M, Seidler D, Clemmer D, Zamfir A
J Am Soc Mass Spectrom
. 2024 Aug;
35(9):2102-2117.
PMID: 39178342
Glycosaminoglycans (GAGs) are sulfated linear -glycan chains abundantly expressed in the extracellular matrix (ECM). Among GAGs, chondroitin sulfate (CS) and dermatan sulfate (DS) play important roles at the brain level,...
8.
Lutomski C, El-Baba T, Clemmer D, Jarrold M
J Am Soc Mass Spectrom
. 2024 Jul;
35(8):2002-2007.
PMID: 39051481
High-density lipoproteins (HDL) are micelle-like particles consisting of a core of triglycerides and cholesteryl esters surrounded by a shell of phospholipid, cholesterol, and apolipoproteins. HDL is considered "good" cholesterol, and...
9.
Couse A, Cox-Vazquez S, Ghatak S, Trinidad J, Clemmer D
J Proteome Res
. 2024 May;
23(6):2288-2297.
PMID: 38805445
In the work presented herein, a simple serial-pelleting purification strategy combined with a mass spectrometry-based proteomics analysis was developed as a means of discerning differences in extracellular vesicle (EV) populations...
10.
Henderson L, Gautam A, Sharon E, Johnson C, Rommel N, Anthony A, et al.
J Am Soc Mass Spectrom
. 2024 May;
35(6):1063-1068.
PMID: 38748611
Bortezomib, a small dipeptide-like molecule, is a proteasome inhibitor used widely in the treatment of myeloma and lymphoma. This molecule reacts with threonine side chains near the center of the...