David Colecchia
Overview
Explore the profile of David Colecchia including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
3407
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Recent Articles
1.
Leonardi M, Perna E, Tronnolone S, Colecchia D, Chiariello M
Autophagy
. 2018 Oct;
15(2):312-326.
PMID: 30289335
Macroautophagy/autophagy is one of the major responses to stress in eukaryotic cells and is implicated in several pathological conditions such as infections, neurodegenerative diseases and cancer. Interestingly, cancer cells take...
2.
Colecchia D, Dapporto F, Tronnolone S, Salvini L, Chiariello M
J Biol Chem
. 2018 Aug;
293(41):15962-15976.
PMID: 30131341
Autophagy, a pathway for bulk protein degradation and removal of damaged organelles, represents one of the major responses of cells to stress, thereby exerting a strict control on their correct...
3.
Pietrobono S, Santini R, Gagliardi S, Dapporto F, Colecchia D, Chiariello M, et al.
Cell Death Dis
. 2018 Feb;
9(2):142.
PMID: 29396391
Aberrant activation of the Hedgehog (HH) signaling is a critical driver in tumorigenesis. The Smoothened (SMO) receptor is one of the major upstream transducers of the HH pathway and a...
4.
Colecchia D, Nicolato E, Ravagli C, Faraoni P, Strambi A, Rossi M, et al.
ACS Med Chem Lett
. 2017 Dec;
8(12):1230-1235.
PMID: 29259739
Head and neck squamous cell carcinomas (HNSCC) are a diverse group of tumors with high morbidity and mortality that have remained mostly unchanged over the past decades. The epidermal growth...
5.
Colecchia D, Stasi M, Leonardi M, Manganelli F, Nolano M, Veneziani B, et al.
Autophagy
. 2017 Nov;
14(6):930-941.
PMID: 29130394
Charcot-Marie-Tooth type 2B (CMT2B) disease is a dominant axonal peripheral neuropathy caused by 5 mutations in the RAB7A gene, a ubiquitously expressed GTPase controlling late endocytic trafficking. In neurons, RAB7A...
6.
Vignaroli G, Iovenitti G, Zamperini C, Coniglio F, Calandro P, Molinari A, et al.
J Med Chem
. 2017 Jun;
60(14):6305-6320.
PMID: 28650650
Pyrazolo[3,4-d]pyrimidines are potent protein kinase inhibitors with promising antitumor activity but suboptimal aqueous solubility, consequently worth being further optimized. Herein, we present the one-pot two-step procedure for the synthesis of...
7.
Monaco I, Camorani S, Colecchia D, Locatelli E, Calandro P, Oudin A, et al.
J Med Chem
. 2017 May;
60(10):4510-4516.
PMID: 28471660
Polymeric nanoparticles (PNPs) may efficiently deliver in vivo therapeutics to tumors when conjugated to specific targeting agents. Gint4.T aptamer specifically recognizes platelet-derived growth factor receptor β and can cross the...
8.
Rossi M, Colecchia D, Ilardi G, Acunzo M, Nigita G, Sasdelli F, et al.
Oncotarget
. 2016 Mar;
7(15):20981-98.
PMID: 26988910
Germ cell tumors (GCT) are the most common malignancies in males between 15 and 35 years of age. Despite the high cure rate, achieved through chemotherapy and/or surgery, the molecular...
9.
Vignaroli G, Calandro P, Zamperini C, Coniglio F, Iovenitti G, Tavanti M, et al.
Sci Rep
. 2016 Feb;
6:21509.
PMID: 26898318
Pyrazolo[3,4-d]pyrimidines are a class of compounds with a good activity against several cancer cell lines. Despite the promising anticancer activity, these molecules showed a poor aqueous solubility. This issue could...
10.
Klionsky D, Abdelmohsen K, Abe A, Abedin M, Abeliovich H, Arozena A, et al.
Autophagy
. 2016 Jan;
12(1):1-222.
PMID: 26799652
No abstract available.