David Chisanga
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Explore the profile of David Chisanga including associated specialties, affiliations and a list of published articles.
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27
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1740
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Recent Articles
1.
Gago da Graca C, Sheikh A, Newman D, Wen L, Li S, Shen J, et al.
Sci Immunol
. 2025 Jan;
10(103):eadn1945.
PMID: 39888981
Stem-like T cells are attractive immunotherapeutic targets in patients with cancer given their ability to proliferate and differentiate into effector progeny. Thus, identifying T cells with enhanced stemness and understanding...
2.
Huber A, Allam A, Dijkstra C, Thiem S, Huynh J, Poh A, et al.
Cell Rep
. 2024 Aug;
43(8):114616.
PMID: 39128004
Although aberrant activation of the KRAS and PI3K pathway alongside TP53 mutations account for frequent aberrations in human gastric cancers, neither the sequence nor the individual contributions of these mutations...
3.
Nightingale R, Reehorst C, Vukelic N, Papadopoulos N, Liao Y, Guleria S, et al.
Dev Cell
. 2024 May;
59(15):1988-2004.e11.
PMID: 38781975
The transcription factor EHF is highly expressed in the lactating mammary gland, but its role in mammary development and tumorigenesis is not fully understood. Utilizing a mouse model of Ehf...
4.
Botchway-Commey E, Adonteng-Kissi O, Meribe N, Chisanga D, Moustafa A, Tembo A, et al.
PLoS One
. 2024 Mar;
19(3):e0298634.
PMID: 38498578
Purpose: Mental health challenges are highly prevalent in African migrants. However, understanding of mental health outcomes in first-generation voluntary African migrants is limited, despite the unique challenges faced by this...
5.
Djajawi T, Pijpers L, Srivaths A, Chisanga D, Chan K, Hogg S, et al.
Cell Rep
. 2024 Feb;
43(3):113831.
PMID: 38401121
Cancer immunotherapies have demonstrated remarkable success; however, the majority of patients do not respond or develop resistance. Here, we conduct epigenetic gene-targeted CRISPR-Cas9 screens to identify epigenomic factors that limit...
6.
Torres S, Man K, Elmzzahi T, Malko D, Chisanga D, Liao Y, et al.
Nat Immunol
. 2024 Feb;
25(3):496-511.
PMID: 38356058
Visceral adipose tissue (VAT) is an energy store and endocrine organ critical for metabolic homeostasis. Regulatory T (T) cells restrain inflammation to preserve VAT homeostasis and glucose tolerance. Here, we...
7.
Thilakasiri P, OKeefe R, To S, Chisanga D, Eissmann M, Carli A, et al.
Life Sci Alliance
. 2023 Nov;
7(2).
PMID: 37957015
Deregulation of the Hippo pathway is a driver for cancer progression and treatment resistance. In the context of gastric cancer, YAP1 is a biomarker for poor patient prognosis. Although genomic...
8.
OKeefe R, Carli A, Baloyan D, Chisanga D, Shi W, Afshar-Sterle S, et al.
Nat Commun
. 2023 Oct;
14(1):6872.
PMID: 37898600
Although gastric cancer is a leading cause of cancer-related deaths, systemic treatment strategies remain scarce. Here, we report the pro-tumorigenic properties of the crosstalk between intestinal tuft cells and type...
9.
Poh A, OBrien M, Chisanga D, He H, Baloyan D, Traichel J, et al.
Cell Rep
. 2022 Oct;
41(2):111479.
PMID: 36223746
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a low 5-year survival rate and is associated with poor response to therapy. Elevated expression of the myeloid-specific hematopoietic cell kinase...
10.
Tsui C, Kretschmer L, Rapelius S, Gabriel S, Chisanga D, Knopper K, et al.
Nature
. 2022 Aug;
609(7926):354-360.
PMID: 35978192
CD8 T cells that respond to chronic viral infections or cancer are characterized by the expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by the...