David Castillo-Azofeifa
Overview
Explore the profile of David Castillo-Azofeifa including associated specialties, affiliations and a list of published articles.
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13
Citations
348
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Recent Articles
1.
Reyes E, Castillo-Azofeifa D, Rispal J, Wald T, Zwick R, Palikuqi B, et al.
J Clin Invest
. 2023 Aug;
133(20).
PMID: 37643009
The gastrointestinal tract relies on the production, maturation, and transit of mucin to protect against pathogens and to lubricate the epithelial lining. Although the molecular and cellular mechanisms that regulate...
2.
Liu Y, Reyes E, Castillo-Azofeifa D, Klein O, Nystul T, Barber D
Nat Commun
. 2023 Jun;
14(1):3745.
PMID: 37353491
Intracellular pH dynamics is increasingly recognized to regulate myriad cell behaviors. We report a finding that intracellular pH dynamics also regulates adult stem cell lineage specification. We identify an intracellular...
3.
Castillo-Azofeifa D, Wald T, Reyes E, Gallagher A, Schanin J, Vlachos S, et al.
Cell Stem Cell
. 2023 Jan;
30(2):188-206.e6.
PMID: 36640764
A central factor in the maintenance of tissue integrity is the response of stem cells to variations in the levels of niche signals. In the gut, intestinal stem cells (ISCs)...
4.
Pentinmikko N, Lozano R, Scharaw S, Andersson S, Englund J, Castillo-Azofeifa D, et al.
Sci Adv
. 2022 Oct;
8(41):eabm1847.
PMID: 36240269
Niche-derived factors regulate tissue stem cells, but apart from the mechanosensory pathways, the effect of niche geometry is not well understood. We used organoids and bioengineered tissue culture platforms to...
5.
McKinley K, Castillo-Azofeifa D, Klein O
Cell Stem Cell
. 2020 May;
26(5):632-656.
PMID: 32386555
Defining the mechanisms that generate specialized cell types and coordinate their functions is critical for understanding organ development and renewal. New tools and discoveries are challenging and refining our definitions...
6.
Bahar Halpern K, Massalha H, Zwick R, Moor A, Castillo-Azofeifa D, Rozenberg M, et al.
Nat Commun
. 2020 Apr;
11(1):1936.
PMID: 32321913
The intestinal epithelium is a structured organ composed of crypts harboring Lgr5+ stem cells, and villi harboring differentiated cells. Spatial transcriptomics have demonstrated profound zonation of epithelial gene expression along...
7.
Sharir A, Marangoni P, Zilionis R, Wan M, Wald T, Hu J, et al.
Nat Cell Biol
. 2019 Sep;
21(9):1102-1112.
PMID: 31481792
The classical model of tissue renewal posits that small numbers of quiescent stem cells (SCs) give rise to proliferating transit-amplifying cells before terminal differentiation. However, many organs house pools of...
8.
Castillo-Azofeifa D, Fazio E, Nattiv R, Good H, Wald T, Pest M, et al.
EMBO J
. 2019 Jan;
38(4).
PMID: 30635334
During homeostasis, the colonic epithelium is replenished every 3-5 days by rapidly cycling stem cells. However, various insults can lead to depletion of stem cells, and colonic epithelium can be...
9.
Castillo-Azofeifa D, Seidel K, Gross L, Golden E, Jacquez B, Klein O, et al.
Development
. 2018 Jun;
145(14).
PMID: 29945863
Adult tongue epithelium is continuously renewed from epithelial progenitor cells, a process that requires hedgehog (HH) signaling. In mice, pharmacological inhibition of the HH pathway causes taste bud loss within...
10.
McKinley K, Stuurman N, Royer L, Schartner C, Castillo-Azofeifa D, Delling M, et al.
Elife
. 2018 Jun;
7.
PMID: 29897330
Cell division is essential to expand, shape, and replenish epithelia. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other...