David C Schriemer
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Explore the profile of David C Schriemer including associated specialties, affiliations and a list of published articles.
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98
Citations
1849
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Recent Articles
1.
Michael A, Amaral B, Ball K, Eiriksson K, Schriemer D
Nat Commun
. 2024 Oct;
15(1):8537.
PMID: 39358380
Crosslinking mass spectrometry (XL-MS) has the potential to map the interactome of the cell with high resolution and depth of coverage. However, current in vivo XL-MS methods are hampered by...
2.
Filandr F, Sarpe V, Raval S, Crowder D, Khan M, Douglas P, et al.
Nat Commun
. 2024 Apr;
15(1):2836.
PMID: 38565885
No abstract available.
3.
Yin J, Keszei A, Houliston S, Filandr F, Beenstock J, Daou S, et al.
Structure
. 2024 Mar;
32(6):795-811.e6.
PMID: 38531363
GCN2 is a stress response kinase that phosphorylates the translation initiation factor eIF2α to inhibit general protein synthesis when activated by uncharged tRNA and stalled ribosomes. The presence of a...
4.
Filandr F, Sarpe V, Raval S, Crowder D, Khan M, Douglas P, et al.
Nat Commun
. 2024 Mar;
15(1):2200.
PMID: 38467655
We present a hydrogen/deuterium exchange workflow coupled to tandem mass spectrometry (HX-MS) that supports the acquisition of peptide fragment ions alongside their peptide precursors. The approach enables true auto-curation of...
5.
Raval S, Douglas P, Laurent D, Khan M, Lees-Miller S, Schriemer D
Anal Chem
. 2023 Oct;
95(43):15884-15892.
PMID: 37851921
Affinity-purification mass spectrometry (AP-MS) is an established technique for identifying protein-protein interactions (PPIs). The basic technology involves immobilizing a high-specificity ligand to a solid-phase support (e.g., an agarose or magnetic...
6.
Syed A, Filandr F, Patterson-Fortin J, Bacolla A, Ravindranathan R, Zhou J, et al.
Nucleic Acids Res
. 2023 Sep;
51(18):9920-9937.
PMID: 37665033
Polymerase theta (Polθ) acts in DNA replication and repair, and its inhibition is synthetic lethal in BRCA1 and BRCA2-deficient tumor cells. Novobiocin (NVB) is a first-in-class inhibitor of the Polθ...
7.
Filandrova R, Douglas P, Zhan X, Verhey T, Morrissy S, Turner R, et al.
J Proteome Res
. 2023 Aug;
22(9):3054-3067.
PMID: 37595185
Multiple methods for quantitative proteomics are available for proteome profiling. It is unclear which methods are most useful in situations involving deep proteome profiling and the detection of subtle distortions...
8.
Crowder D, Sarpe V, Amaral B, Brodie N, Michael A, Schriemer D
Anal Chem
. 2023 Apr;
95(15):6425-6432.
PMID: 37022750
Crosslinking mass spectrometry (XL-MS) is a valuable technique for generating point-to-point distance measurements in protein space. However, cell-based XL-MS experiments require efficient software that can detect crosslinked peptides with sensitivity...
9.
Rey M, Yang M, Lee L, Zhang Y, Sheff J, Sensen C, et al.
Sci Rep
. 2023 Jan;
13(1):956.
PMID: 36653429
No abstract available.
10.
Geddes-McAlister J, Schriemer D
Expert Rev Proteomics
. 2022 Dec;
19(4-6):231-233.
PMID: 36511641
The 13 annual Canadian National Proteomics Network was held in May 2022 in Montreal, Quebec, Canada. More than 175 individuals participated in this dynamic and productive meeting either in-person or...